Johann Brandstetter

Publikationen

Publikationen pro Jahr 1992 2013 2014 2016 2018 2019 2021 2022 2024

• 124 Artikel
• 12 Abstract
• 11 Sonstiger Beitrag
• 10 Poster
• 13 Mehr
  • 8 Review article
  • 2 Paper
  • 1 Meeting-Abstract
  • 1 Letter
  • 1 Patentschrift

Publikationen pro Jahr

Publikationen pro Jahr

Suchergebnisse

• 2024

  Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors

  Lange, R. W., Bloch, K., Heindl, M. R., Wollenhaupt, J., Weiss, M. S., Brandstetter, H., Klebe, G., Falcone, F. H., Boettcher-Friebertshaeuser, E., Dahms, S. O. & Steinmetzer, T., 2 Mai 2024, in: CHEMMEDCHEM. 19, 9, 15 S., e202400057.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

• A conserved strategy to attack collagen: The activator domain in bacterial collagenases unwinds triple- helical collagen

  Serwanja, J., Wieland, A. C., Haubenhofer, A., Brandstetter, H. & Schoenauer, E., 16 Apr. 2024, in: Proceedings of the National Academy of Sciences of the United States of America. 121, 16, 12 S., e2321002121.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access
• 2023

  Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections: ACS Central Science

  Konstantinović, J., Kany, A. M., Alhayek, A., Abdelsamie, A. S., Sikandar, A., Voos, K., Yao, Y., Andreas, A., Shafiei, R., Loretz, B., Schönauer, E., Bals, R., Brandstetter, H., Hartmann, R. W., Ducho, C., Lehr, C.-M., Beisswenger, C., Müller, R., Rox, K. & Haupenthal, J. &1 mehr, Hirsch, A. K. H., 27 Dez. 2023, in: ACS Central Science. 9, 12, S. 2205-2215 11 S.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• Arabidopsis thaliana Phytocystatin 6 Forms Functional Oligomer and Amyloid Fibril States

  Santos, N. P., Brandstetter, H. & Dall, E., 5 Dez. 2023, in: Biochemistry. 62, 23, S. 3420-3429 10 S.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• Phytocystatin 6 is a context-dependent, tight-binding inhibitor of <i>Arabidopsis thaliana</i> legumain isoform β

  Santos, N. P., Soh, W. T., Demir, F., Tenhaken, R., Briza, P., Huesgen, P. F., Brandstetter, H. & Dall, E., Dez. 2023, in: Plant Journal. 116, 6, S. 1681-1695 15 S.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• Quantitative cross-linking via engineered cysteines to study inter-domain interactions in bacterial collagenases.

  Serwanja, J., Brandstetter, H. & Schönauer, E., 20 Aug. 2023, in: STAR protocols. 4, 3, 102519.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• Legumain Functions as a Transient TrkB Sheddase

  Holzner, C., Bottinger, K., Blochl, C., Huber, C., Dahms, S., Dall, E. & Brandstetter, H., 11 März 2023. 15 S.

  Publikation: Konferenzbeitrag › Paper › Peer-reviewed

  Open Access

• Legumain Functions as a Transient TrkB Sheddase

  Holzner, C., Böttinger, K., Blöchl, C., Huber, C. G., Dahms, S. O., Dall, E. & Brandstetter, H., 11 März 2023, in: International Journal of Molecular Sciences. 24, 6, 5394.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access
• 2022

  Legumain Activity Is Controlled by Extended Active Site Residues and Substrate Conformation

  Mohmmed, T. E. E., Brandstetter, H. & Dall, E., 19 Okt. 2022, in: International Journal of Molecular Sciences. 23, 20, 12548.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• The Fluorescent Enzyme Cascade Detects Low Abundance Protein Modifications Suitable for the Assembly of Functionally Annotated Modificatome Databases

  Hoppe, I. J., Prommegger, B., Uhl, A., Lohrig, U., Huber, C. G. & Brandstetter, H., 6 Okt. 2022, in: ChemBioChem. 23, 19, e202200399.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• Legumain - an unusal lysosomal protease

  Brandstetter, H., 5 Okt. 2022.

  Publikation: Konferenzbeitrag › Poster

• Legumain Activity is Controlled by Extended Active Site Residues and Substrate Conformation

  Elamin, T., Brandstetter, H. & Dall, E., Okt. 2022. 16 S.

  Publikation: Konferenzbeitrag › Paper › Peer-reviewed

• Structural and functional studies of legumain-mycocypin complexes revealed a competitive, exosite-regulated mode of interaction

  Mohmmed, T. E. E., Santos, N., Briza, P., Brandstetter, H. & Dall, E., Okt. 2022, in: Journal of Biological Chemistry. 298, 10, 102502.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• Legumain functions as a transient TrkB sheddase

  Brandstetter, H., 12 Sept. 2022.

  Publikation: Konferenzbeitrag › Poster

• Sensitive PTM detection by fluorescent enzyme cascades (fEC)

  Brandstetter, H., 13 Mai 2022.

  Publikation: Konferenzbeitrag › Poster

• Structure, activation, activities, regulation of legumain: Lessons for and from metacaspases?

  Brandstetter, H., 11 Mai 2022.

  Publikation: Konferenzbeitrag › Poster

• N-Aryl-2-iso-butylmercaptoacetamides: the discovery of highly potent and selective inhibitors of Pseudomonas aeruginosa virulence factor LasB and Clostridium histolyticum virulence factor ColH

  Voos, K., Yahiaoui, S., Konstantinović, J., Schönauer, E., Alhayek, A., Sikandar, A., Chaib, K. S., Ramspoth, T., Rox, K., Haupenthal, J., Köhnke, J., Brandstetter, H., Ducho, C. & Hirsch, A., 25 Apr. 2022

  Publikation: Andere Beiträge › Sonstiger Beitrag › Forschung

• Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa

  Kaya, C., Walter, I., Alhayek, A., Shafiei, R., Jézéquel, G., Andreas, A., Konstantinović, J., Schönauer, E., Sikandar, A., Haupenthal, J., Müller, R., Brandstetter, H., Hartmann, R. W. & Hirsch, A. K. H., 22 Apr. 2022, in: ACS Infectious Diseases. 8, 5, S. 1010-1021 12 S.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• Dichlorophenylpyridine-Based Molecules Inhibit Furin through anInduced-Fit Mechanism

  Dahms, S. O., Schnapp, G., Winter, M., Buttner, F. H., KG, B., KG, B., KG, B. & Brandstetter, H., 15 Apr. 2022, in: ACS CHEMICAL BIOLOGY. 17, 4, S. 816-821 6 S.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• Inhibition of Collagenase Q1 of Bacillus cereus as a Novel Antivirulence Strategy for the Treatment of Skin‐Wound Infections

  Alhayek, A., Khan, E. S., Schönauer, E., Shafiei, R., Voos, K., Han, M. K. L., Ducho, C., Posselt, G., Wessler, S., Brandstetter, H., Haupenthal, J., Del Campo, A. & Hirsch, A. K. H., März 2022, in: Advanced Therapeutics. 5, 3, S. 2100222 2100222.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases

  Alhayek, A., Abdelsamie, A. S., Schönauer, E., Camberlein, V., Hutterer, E., Posselt, G., Serwanja, J., Blöchl, C., Huber, C. G., Haupenthal, J., Brandstetter, H., Wessler, S. & Hirsch, A. K. H., 2022, in: Journal of Medicinal Chemistry. 65, 19, S. 12933-12955 23 S.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• Production of Functional Plant Legumain Proteases Using the Leishmania tarentolae Expression System

  Dall, E., Licht, A. & Brandstetter, H., 2022, in: Methods in molecular biology (Clifton, N.J.). 2447, S. 35-51 17 S.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed
• 2021

  Proteolytic Profiling of Streptococcal Pyrogenic Exotoxin B (SpeB) by Complementary HPLC-MS Approaches

  Blöchl, C., Holzner, C., Luciano, M., Bauer, R., Horejs-Hoeck, J., Eckhard, U., Brandstetter, H. & Huber, C. G., 30 Dez. 2021, in: International Journal of Molecular Sciences. 23, 1, 412.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• The nanotopography of SiO2 particles impacts the selectivity and 3D fold of bound allergens

  Mills-Goodlet, R. D., Johnson, L., Hoppe, I. J., Regl, C., Geppert, M., Schenck, M. M. H., Huber, S., Hauser, M., Ferreira, F., Hüsing, N., Huber, C. G., Brandstetter, H., Duschl, A. & Himly, M., 6 Nov. 2021, in: Nanoscale. 13, 48, S. 20508-20520 13 S.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• Structural Alterations of Antigens at the Material Interface: An Early Decision Toolbox Facilitating Safe-by-Design Nanovaccine Development

  Johnson, L., Aglas, L., Soh, W. T., Geppert, M., Hofer, S., Hofstätter, N., Briza, P., Ferreira, F., Weiss, R., Brandstetter, H., Duschl, A. & Himly, M., 8 Okt. 2021, in: International Journal of Molecular Sciences. 22, 19, 10895.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• The Peptide Ligase Activity of Human Legumain Depends on Fold Stabilization and Balanced Substrate Affinities

  Dall, E., Stanojlovic, V., Demir, F., Briza, P., Dahms, S. O., Huesgen, P. F., Cabrele, C. & Brandstetter, H., 1 Okt. 2021, in: ACS CATALYSIS. 11, 19, S. 11885-11896 12 S.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• OFF-State-Specific Inhibition of the Proprotein Convertase Furin

  Dahms, S. O., Haider, T., Klebe, G., Steinmetzer, T. & Brandstetter, H., 17 Sept. 2021, in: ACS CHEMICAL BIOLOGY. 16, 9, S. 1692-1700 9 S.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• In vitro immuno-nanotoxicological methods that take pre-existing conditions into account

  Himly, M., Johnson, L., Hasenkopf, I., Punz, B., Mills-Goodlet, R. D., Geppert, M., Hofer, S., Hofstätter, N., Aglas, L., Ferreira, F., Brandstetter, H. & Duschl, A., 30 Juni 2021.

  Publikation: Konferenzbeitrag › Abstract › Peer-reviewed

• Structure of human factor VIIa-soluble tissue factor with calcium, magnesium and rubidium

  Vadivel, K., Schmidt, A. E., Cascio, D., Padmanabhan, K., Krishnaswamy, S., Brandstetter, H. & Bajaj, S. P., 1 Juni 2021, in: Acta Crystallographica Section D: Structural Biology. 77, Pt 6, S. 809-819 11 S.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

• A toolbox for early-stage suitability assessment of (nano-)particulate systems in AIT vaccine development

  Johnson, L., Aglas, L., Soh, W. T., Geppert, M., Hofer, S., Hofstätter, N., Briza, P., Ferreira, F., Weiss, R., Brandstetter, H., Duschl, A. & Himly, M., 30 Apr. 2021.

  Publikation: Konferenzbeitrag › Abstract › Peer-reviewed

• The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin

  Lam van, T. V., Heindl, M. R., Schlutt, C., Böttcher-Friebertshäuser, E., Bartenschlager, R., Klebe, G., Brandstetter, H., Dahms, S. O. & Steinmetzer, T., 11 März 2021, in: ACS Medicinal Chemistry Letters. 12, 3, S. 426-432 7 S.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• Biochemical characterisation of a collagenase from Bacillus cereus strain Q1

  Hoppe, I. J., Brandstetter, H. & Schönauer, E., 18 Feb. 2021, in: Scientific Reports. 11, 1, S. 4187 4187.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

• Phosphonate as Stable Zinc-binding Group for Inhibitors of Clostridial Collagenase H (ColH) as Pathoblocker Agents.

  Voos, K., Schönauer, E., Alhayek, A., Haupenthal, J., Andreas, A., Müller, R., Hartmann, R., Brandstetter, H., Hirsch, A. & Ducho, C., Jan. 2021, in: CHEMMEDCHEM.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed
• 2020

  Studying the stages of immune activation/modulation by silica nanoparticle-allergen conjugates: applying the AOP concept to immunotherapy development

  Johnson, L., Aglas, L., Geppert, M., Hofer, S., Hofstätter, N., Soh, W. T., Ferreira, F., Brandstetter, H., Duschl, A. & Himly, M., 18 Nov. 2020.

  Publikation: Konferenzbeitrag › Abstract › Peer-reviewed

• Structural and functional studies of Arabidopsis thaliana legumain beta reveal isoform specific mechanisms of activation and substrate recognition

  Dall, E., Zauner, F., Soh, W. T., Demir, F., Dahms, S., Cabrele, C., Huesgen, P. F. & Brandstetter, H., 11 Sept. 2020, in: Journal of Biological Chemistry. 295, 37, S. 13047-13064 18 S.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• In silico Design of Phl p 6 Variants With Altered Fold-Stability Significantly Impacts Antigen Processing, Immunogenicity and Immune Polarization

  Winter, P., Stubenvoll, S., Scheiblhofer, S., Joubert, I. A., Strasser, L., Briganser, C., Soh, W. T., Hofer, F., Kamenik, A. S., Dietrich, V., Michelini, S., Laimer, J., Lackner, P., Horejs-Hoeck, J., Tollinger, M., Liedl, K. R., Brandstetter, J., Huber, C. G. & Weiss, R., 18 Aug. 2020, in: Frontiers in Immunology. 11, S. 1-21 21 S., 1824.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• N-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases

  Konstantinović, J., Yahiaoui, S., Alhayek, A., Haupenthal, J., Schönauer, E., Andreas, A., Kany, A. M., Müller, R., Koehnke, J., Berger, F. K., Bischoff, M., Hartmann, R. W., Brandstetter, H. & Hirsch, A. K. H., 13 Aug. 2020, in: Journal of Medicinal Chemistry. 63, 15, S. 8359-8368 10 S.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• Silica nanoparticles as novel adjuvant for allergen-specidic immunotherapy: impact on allergen processing

  Johnson, L., Aglas, L., Geppert, M., Hofer, S., Hofstätter, N., Soh, W. T., Briza, P., Ferreira, F., Brandstetter, H., Duschl, A. & Himly, M., Juni 2020.

  Publikation: Konferenzbeitrag › Abstract › Peer-reviewed

• Ligand Binding of PR-10 Proteins with a Particular Focus on the Bet v 1 Allergen Family

  Aglas, L., Soh, W., Kraiem, A., Wenger, M., Brandstetter, H. & Ferreira, F., 19 Mai 2020, in: Current Allergy and Asthma Reports. 20, 7, S. 25 25.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

• ExteNDing Proteome Coverage with Legumain as a Highly Specific Digestion Protease

  Soh, W. T., Demir, F., Dall, E., Perrar, A., Dahms, S., Kuppusamy, M., Brandstetter, H. & Huesgen, P. F., 2020, in: Analytical Chemistry. 92, 4, S. 2961-2971 11 S.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• Identification and characterization of the proteolytic flagellin from the common freshwater bacterium Hylemonella gracilis

  Eckhard, U. (Korrespondierende/r Autor/in), Blöchl, C., Jenkins, B. G., Mansfield, M. J., Huber, C. G., Doxey, A. C. & Brandstetter, H., 2020, in: Scientific Reports. 10, 1, 19052.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access
• 2019

  Boiling down the cysteine-stabilized LTP fold - loss of structural and immunological integrity of allergenic Art v 3 and Pru p 3 as a consequence of irreversible lanthionine formation

  Wildner, S., Griessner, I., Stemeseder, T., Regl, C., Soh, W. T., Stock, L. G., Völker, T., Alessandri, C., Mari, A., Huber, C. G., Stutz, H., Brandstetter, H. & Gadermaier, G., 1 Dez. 2019, in: Molecular Immunology. 116, S. 140-150 11 S.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• Multiple roles of Bet v 1 ligands in allergen stabilization and modulation of endosomal protease activity

  Soh, W. T., Aglas, L., Mueller, G. A., Gilles, S., Weiss, R., Scheiblhofer, S., Huber, S., Scheidt, T., Thompson, P. M., Briza, P., London, R. E., Traidl-Hoffmann, C., Cabrele, C., Brandstetter, H. & Ferreira, F., Dez. 2019, in: Allergy: European Journal of Allergy and Clinical Immunology. 74, 12, S. 2382-2393 12 S.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• Surface loops of trypsin-like serine proteases as determinants of function

  Goettig, P., Brandstetter, H. & Magdolen, V., Nov. 2019, in: Biochimie. 166, S. 52-76 25 S.

  Publikation: Beitrag in Fachzeitschrift › Review article › Peer-reviewed

  Open Access

• Discovery and characterization of trypanocidal cysteine protease inhibitors from the 'malaria box'

  Pereira, G. A. N., da Silva, E. B., Braga, S. F. P., Leite, P. G., Martins, L. C., Vieira, R. P., Soh, W. T., Villela, F. S., Costa, F. M. R., Ray, D., de Andrade, S. F., Brandstetter, H., Oliveira, R. B., Caffrey, C. R., Machado, F. S. & Ferreira, R. S., 1 Okt. 2019, in: European Journal of Medicinal Chemistry. 179, S. 765-778 14 S.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• Analytical Cascades of Enzymes for Sensitive Detection of Structural Variations in Protein Samples

  Hollerweger, J., Hoppe, I. J., Regl, C., Stock, L. G., Huber, C. G., Lohrig, U., Stutz, E.-H. & Brandstetter, H. (Korrespondierende/r Autor/in), 19 Sept. 2019.

  Publikation: Konferenzbeitrag › Poster

• ExteNDing proteome coverage with legumain as highly specific digestion protease

  Soh, W. T., Demir, F., Dall, E., Dahms, S., Brandstetter, H. & Huesgen, P. F., 18 Sept. 2019.

  Publikation: Konferenzbeitrag › Poster

• Dual-role of Bet V 1 ligands in the processing by endolysosomal proteases

  Soh, W. T., Aglas, L., Mueller, G. A., Gilles, S., Huber, S., Scheidt, T., Thompson, P. M., Briza, P., London, R. E., Traidl-Hoffmann, C., Cabrele, C., Brandstetter, H. & Ferreira, F., Aug. 2019, in: ALLERGY: European Journal of Allergy and Clinical Immunology. 74, S. 137-137

  Publikation: Beitrag in Fachzeitschrift › Meeting-Abstract › Peer-reviewed

  Open Access

• Maturation of coagulation factor IX during Xase formation as deduced using factor VIII-derived peptides

  Fang, H., Zögg, T. & Brandstetter, H., Aug. 2019, in: FEBS Open Bio. 9, 8, S. 1370-1378 9 S.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access

• Cruzain structures: apocruzain and cruzain bound to S-methyl thiomethanesulfonate and implications for drug design

  Barbosa da Silva, E., Dall, E., Briza, P., Brandstetter, H. & Ferreira, R. S., 1 Juni 2019, in: Acta Crystallographica Section F: Structural Biology Communications. 75, 6, S. 419-427 9 S.

  Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

  Open Access