Regulation of cutaneous tissue-repair by a specialized population of CD4+ T cells

    Projektdetails

    Beschreibung

    In healthy individuals T cells in the skin not only combat infection but also work in concert to help maintain normal tissue homeostasis and promote wound repair. We have identified a novel population of CLA+CD4+ T cells in the peripheral blood of healthy subjects, and we hypothesize that this is a regulatory population of skin-tropic T cells that participates in the wound healing response. In this proposal, we will use in vitro analyses and innovative humanized mouse models to test this hypothesis, assessing the developmental origins of CLA+CD103+ cells, examining their antigen-specificity, and determining their function during cutaneous inflammation and wound healing.

    In this proposal, we will use in vitro analyses and innovative humanized mouse models to test this hypothesis, assessing the developmental origins of CD103+CLAhi cells, examining their antigen-specificity, and determining their function during cutaneous wound healing.

    Specific Aim 1 – Determine the developmental relationship of CD103+CLAhicells with T cell populations in the skin, and examine the molecular requirements for CD103+CLAhi cell differentiation. Specific Aim 2 – Assess the antigen-specificity of CD103+CLAhicells Specific Aim 3 – Determine the function of CD103+CLAhicells using humanized mouse models of cutaneous wound healing.
    KurztitelNIH – wound healing
    StatusLaufend
    Tatsächlicher Beginn/ -es Ende20/06/1719/06/22

    Systematik der Wissenschaftszweige 2012

    • 302 Klinische Medizin
    • 301 Medizinisch-theoretische Wissenschaften, Pharmazie
    • 106 Biologie

    Systematik der Wissenschaftszweige 2002

    • 3411 Immunologie
    • 1409 Humanbiologie
    • 3508 Dermatologie
    • 1411 Molekularbiologie

    Systematik der Wissenschaftszweige 2012 (6-Steller)

    • 106018 Humanbiologie
    • 301902 Immunologie
    • 302011 Dermatologie
    • 106023 Molekularbiologie