Cortical Morphometry and Its Relationship with Cognitive Functions in Children after non-CNS Cancer

Janine Sophie Spitzhüttl; Martin Kronbichler; Lisa Kronbichler; Valentin Benzing; Valerie Siegwart; Mirko Schmidt; Manuela Pastore‐Wapp; Claus Kiefer; Nedelina Slavova; Michael Grotzer; Maja Steinlin; Claudia M. Roebers; Kurt Leibundgut; Regula Everts

doi:10.1080/17518423.2021.1898059

Cortical Morphometry and Its Relationship with Cognitive Functions in Children after non-CNS Cancer

Janine Sophie Spitzhüttl, Martin Kronbichler, Lisa Kronbichler, Valentin Benzing, Valerie Siegwart, Mirko Schmidt, Manuela Pastore‐Wapp, Claus Kiefer, Nedelina Slavova, Michael Grotzer, Maja Steinlin, Claudia M. Roebers, Kurt Leibundgut, Regula Everts^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

Abstract

Background: Childhood cancer survivors (Ccs) are at risk for cognitive late-effects, which might result from cortical alterations, even if cancer does not affect the brain. The study aimed to examine gray and white matter volume and its relationship to cognition. Methods: Forty-three Ccs of non-central nervous system cancers and 43 healthy controls, aged 7–16 years, were examined. Cognitive functions and fine motor coordination were assessed and T1-weighted images were collected for voxel-based morphometry.
Results: Executive functions (p = .024, d = .31) were poorer in Ccs than controls, however still within the normal range. The volume of the amygdala (p = .011, ŋ2 = .117) and the striatum (p = .03, ŋ2 = .102) was reduced in Ccs. No significant structure–function correlations were found, neither in patients nor controls.
Conclusion: Non-CNS childhood cancer and its treatment impacts on brain structures relevant to emotion processing.

Originalsprache	Englisch
Seiten (von - bis)	266-275
Seitenumfang	10
Fachzeitschrift	Developmental Neurorehabilitation
Jahrgang	24
Ausgabenummer	4
Frühes Online-Datum	16 März 2021
DOIs	https://doi.org/10.1080/17518423.2021.1898059
Publikationsstatus	Veröffentlicht - Apr. 2021

Bibliographische Notiz

Funding Information:
This work was supported by the Fondation Gaydoul (Pf?ffikon SZ), the Swiss Cancer Research Foundation (KFS-3705-08-2015 and KFS-4708-02-2019), the Dietmar Hopp Stiftung GmbH (Walldorf, Germany), the Krebsstiftung Thun-Berner Oberland (Thun, Switzerland), the Berner Stiftung f?r krebskranke Kinder, and the Hans & Annelies Swierstra Stiftung (Meggen, Switzerland). The funding body had no role in the design of the study, collection, analysis, and interpretation of the data, or in writing the manuscript; Dietmar Hopp Stiftung; Fondation Gaydoul; Swiss Cancer Research Foundation; Hans und Annelies Swierstra Stiftung;Krebsstiftung Thun-Berner Oberland The authors thank all children and adolescents as well as their parents for their participation. Furthermore, we would like to thank the Fondation Gaydoul (Churerstrasse 47, 8808 Pf?ffikon SZ), the Swiss Cancer Research foundation (KFS-3705-08-2015 and 4708-02-2019), the Dietmar Hopp Stiftung GmbH (Walldorf, Germany), the Krebsstiftung Thun-Berner Oberland (Thun, Switzerland), the Berner Stiftung f?r krebskranke Kinder?and the Hans & Annelies Swierstra Stiftung (Meggen, Switzerland) for their support in funding. Additionally, we would like to thank the team of the Swiss Childhood Cancer Registry for their help. Special thanks go to all master students and study assistants for their support in performing assessments and to Stephanie Abgottspon for her help in editing the manuscript.

Systematik der Wissenschaftszweige 2012

501 Psychologie

Zugriff auf Dokument

10.1080/17518423.2021.1898059

Andere Dateien und Links

Dieses zitieren

Spitzhüttl, J. S., Kronbichler, M., Kronbichler, L., Benzing, V., Siegwart, V., Schmidt, M., Pastore‐Wapp, M., Kiefer, C., Slavova, N., Grotzer, M., Steinlin, M., Roebers, C. M., Leibundgut, K., & Everts, R. (2021). Cortical Morphometry and Its Relationship with Cognitive Functions in Children after non-CNS Cancer. Developmental Neurorehabilitation, 24(4), 266-275. https://doi.org/10.1080/17518423.2021.1898059

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title = "Cortical Morphometry and Its Relationship with Cognitive Functions in Children after non-CNS Cancer",

abstract = "Background: Childhood cancer survivors (Ccs) are at risk for cognitive late-effects, which might result from cortical alterations, even if cancer does not affect the brain. The study aimed to examine gray and white matter volume and its relationship to cognition. Methods: Forty-three Ccs of non-central nervous system cancers and 43 healthy controls, aged 7–16 years, were examined. Cognitive functions and fine motor coordination were assessed and T1-weighted images were collected for voxel-based morphometry. Results: Executive functions (p = .024, d = .31) were poorer in Ccs than controls, however still within the normal range. The volume of the amygdala (p = .011, {\ng}2 = .117) and the striatum (p = .03, {\ng}2 = .102) was reduced in Ccs. No significant structure–function correlations were found, neither in patients nor controls. Conclusion: Non-CNS childhood cancer and its treatment impacts on brain structures relevant to emotion processing.",

keywords = "Childhood cancer survivors, voxel-based morphometry, gray and white matter volume, cognitive late-effects, non-central nervous system cancers",

author = "Spitzh{\"u}ttl, {Janine Sophie} and Martin Kronbichler and Lisa Kronbichler and Valentin Benzing and Valerie Siegwart and Mirko Schmidt and Manuela Pastore‐Wapp and Claus Kiefer and Nedelina Slavova and Michael Grotzer and Maja Steinlin and Roebers, {Claudia M.} and Kurt Leibundgut and Regula Everts",

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doi = "10.1080/17518423.2021.1898059",

language = "English",

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Spitzhüttl, JS, Kronbichler, M, Kronbichler, L, Benzing, V, Siegwart, V, Schmidt, M, Pastore‐Wapp, M, Kiefer, C, Slavova, N, Grotzer, M, Steinlin, M, Roebers, CM, Leibundgut, K & Everts, R 2021, 'Cortical Morphometry and Its Relationship with Cognitive Functions in Children after non-CNS Cancer', Developmental Neurorehabilitation, Jg. 24, Nr. 4, S. 266-275. https://doi.org/10.1080/17518423.2021.1898059

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T1 - Cortical Morphometry and Its Relationship with Cognitive Functions in Children after non-CNS Cancer

AU - Spitzhüttl, Janine Sophie

AU - Kronbichler, Martin

AU - Kronbichler, Lisa

AU - Benzing, Valentin

AU - Siegwart, Valerie

AU - Schmidt, Mirko

AU - Pastore‐Wapp, Manuela

AU - Kiefer, Claus

AU - Slavova, Nedelina

AU - Grotzer, Michael

AU - Steinlin, Maja

AU - Roebers, Claudia M.

AU - Leibundgut, Kurt

AU - Everts, Regula

PY - 2021/4

Y1 - 2021/4

N2 - Background: Childhood cancer survivors (Ccs) are at risk for cognitive late-effects, which might result from cortical alterations, even if cancer does not affect the brain. The study aimed to examine gray and white matter volume and its relationship to cognition. Methods: Forty-three Ccs of non-central nervous system cancers and 43 healthy controls, aged 7–16 years, were examined. Cognitive functions and fine motor coordination were assessed and T1-weighted images were collected for voxel-based morphometry. Results: Executive functions (p = .024, d = .31) were poorer in Ccs than controls, however still within the normal range. The volume of the amygdala (p = .011, ŋ2 = .117) and the striatum (p = .03, ŋ2 = .102) was reduced in Ccs. No significant structure–function correlations were found, neither in patients nor controls. Conclusion: Non-CNS childhood cancer and its treatment impacts on brain structures relevant to emotion processing.

AB - Background: Childhood cancer survivors (Ccs) are at risk for cognitive late-effects, which might result from cortical alterations, even if cancer does not affect the brain. The study aimed to examine gray and white matter volume and its relationship to cognition. Methods: Forty-three Ccs of non-central nervous system cancers and 43 healthy controls, aged 7–16 years, were examined. Cognitive functions and fine motor coordination were assessed and T1-weighted images were collected for voxel-based morphometry. Results: Executive functions (p = .024, d = .31) were poorer in Ccs than controls, however still within the normal range. The volume of the amygdala (p = .011, ŋ2 = .117) and the striatum (p = .03, ŋ2 = .102) was reduced in Ccs. No significant structure–function correlations were found, neither in patients nor controls. Conclusion: Non-CNS childhood cancer and its treatment impacts on brain structures relevant to emotion processing.

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