Projekte pro Jahr
Abstract
Introduction: Hormonal contraceptives (HCs), nowadays one of the most used contraceptive methods, downregulate endogenous ovarian hormones, which have multiple plastic effects in the adult brain. HCs usually contain a synthetic estrogen, ethinyl-estradiol, and a synthetic progestin, which can be classified as androgenic or anti-androgenic, depending on their interaction with androgen receptors. Both the anterior cingulate cortex (ACC) and the amygdala express steroid receptors and have shown differential functionality depending on the hormonal status of the participant and the use of HC. In this work, we investigated for the first time the relationship between ACC and amygdala resting state functional connectivity (rs-FC) and HC use duration, while controlling for progestin androgenicity.
Methods: A total of 231 healthy young women participated in five different magnetic resonance imaging studies and were included in the final analysis. The relation between HC use duration and (i) gray matter volume, (ii) fractional amplitude of low-frequency fluctuations, and (iii) seed-based connectivity during resting state in the amygdalae and ACC was investigated in this large sample of women.
Results: In general, rs-FC of the amygdalae with frontal areas, and between the ACC and temporoparietal areas, decreased the longer the HC exposure and independently of the progestin’s androgenicity. The type of HC’s progestin did show a differential effect in the gray matter volume of left ACC and the connectivity between bilateral ACC and the right inferior frontal gyrus.
Methods: A total of 231 healthy young women participated in five different magnetic resonance imaging studies and were included in the final analysis. The relation between HC use duration and (i) gray matter volume, (ii) fractional amplitude of low-frequency fluctuations, and (iii) seed-based connectivity during resting state in the amygdalae and ACC was investigated in this large sample of women.
Results: In general, rs-FC of the amygdalae with frontal areas, and between the ACC and temporoparietal areas, decreased the longer the HC exposure and independently of the progestin’s androgenicity. The type of HC’s progestin did show a differential effect in the gray matter volume of left ACC and the connectivity between bilateral ACC and the right inferior frontal gyrus.
Originalsprache | Englisch |
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Aufsatznummer | 1131995 |
Seitenumfang | 11 |
Fachzeitschrift | Frontiers in Endocrinology |
Jahrgang | 14 |
DOIs | |
Publikationsstatus | Veröffentlicht - 13 Juli 2023 |
Bibliographische Notiz
Funding Information:This research was funded by the Austrian Science Fund (FWF) Project P32276 supporting BP; the PhD Programme “Imaging the Mind: Connectivity and Higher Cognitive Function” [W 1233-G17] supporting EH-L and IN; and the European Research Council (ERC) Starting Grant 850953 supporting BP and EH-L.
Publisher Copyright:
Copyright © 2023 Hidalgo-Lopez, Noachtar and Pletzer.
Systematik der Wissenschaftszweige 2012
- 501 Psychologie
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BECONTRA: How Birth Control Pills affect the Female Brain
Pletzer, B. A. (Projektleitung)
1/06/20 → 31/05/26
Projekt: Forschung
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Doktoratskolleg Imaging the Mind: Connectedness of Cognitive Domains
Schabus, M. (Projektleitung), Wilhelm, F. (Projektmitarbeiter/in), Blechert, J. (Projektmitarbeiter/in), Hödlmoser, K. (Projektmitarbeiter/in), Hutzler, F. (Projektmitarbeiter/in), Jonas, E. (Projektmitarbeiter/in), Perner, J. (Projektmitarbeiter/in), Weisz, N. (Projektmitarbeiter/in), Pletzer, B. A. (Projektmitarbeiter/in) & Kronbichler, M. (Projektmitarbeiter/in)
1/03/19 → 31/08/24
Projekt: Forschung