Molecular machines for protein degradation

Michael Groll, Matthias Bochtler, Hans Brandstetter, Tim Clausen, Robert Huber

Publikation: Beitrag in FachzeitschriftReview article

Abstract

One of the most precisely regulated processes in living cells is intracellular protein degradation. The main component of the degradation machinery is the 20S proteasome present in both eukaryotes and prokaryotes. In addition, there exist other proteasome-related protein-degradation machineries, like HslVU in eubacteria. Peptides generated by proteasomes and related systems can be used by the cell, for example, for antigen presentation. However, most of the peptides must be degraded to single amino acids, which are further used in cell metabolism and for the synthesis of new proteins. Tricorn protease and its interacting factors are working downstream of the proteasome and process the peptides into amino acids. Here, we summarise the current state of knowledge about protein-degradation systems, focusing in particular on the proteasome, HslVU, Tricorn protease and its interacting factors and DegP. The structural information about these protein complexes opens new possibilities for identifying, characterising and elucidating the mode of action of natural and synthetic inhibitors, which affects their function. Some of these compounds may find therapeutic applications in contemporary medicine.

OriginalspracheEnglisch
Seiten (von - bis)222-56
Seitenumfang35
FachzeitschriftChemBioChem : European Journal of Chemical Biology
Jahrgang6
Ausgabenummer2
DOIs
PublikationsstatusVeröffentlicht - Feb 2005

Systematik der Wissenschaftszweige 2012

  • 106 Biologie

Zitieren

Groll, M., Bochtler, M., Brandstetter, H., Clausen, T., & Huber, R. (2005). Molecular machines for protein degradation. ChemBioChem : European Journal of Chemical Biology, 6(2), 222-56. https://doi.org/10.1002/cbic.200400313