TY - JOUR
T1 - Recognition and perception of emotions in juvenile myoclonic epilepsy
AU - Rainer, Lucas Johannes
AU - Kuchukhidze, Giorgi
AU - Trinka, Eugen
AU - Braun, Mario
AU - Kronbichler, Martin
AU - Langthaler, Patrick
AU - Zimmermann, Georg
AU - Kronbichler, Lisa
AU - Said-Yürekli, Sarah
AU - Kirschner, Margarita
AU - Zamarian, Laura
AU - Schmid, Elisabeth
AU - Jokeit, Hennric
AU - Höfler, Julia
PY - 2023/12
Y1 - 2023/12
N2 -
Objective
Perception and recognition of emotions are fundamental
prerequisites of human life. Patients with juvenile myoclonic epilepsy
(JME) may have emotional and behavioral impairments that might influence
socially desirable interactions. We aimed to investigate perception and
recognition of emotions in patients with JME by means of
neuropsychological tests and functional magnetic resonance imaging
(fMRI).
Methods
Sixty-five patients with JME (median age = 27 years,
interquartile range [IQR] = 23–34) were prospectively recruited at the
Department of Neurology, Christian Doppler University Hospital,
Paracelsus Medical University, Salzburg, Austria. Patients were compared
to 68 healthy controls (median age = 24 years, IQR = 21–31), matched
for sex, age, and education. All study participants underwent the
Networks of Emotion Processing test battery (NEmo), an fMRI paradigm of
“dynamic fearful faces,” a structured interview for psychiatric and
personality disorders, and comprehensive neuropsychological testing.
Results
JME patients versus healthy controls demonstrated
significant deficits in emotion recognition in facial and verbal tasks
of all emotions, especially fear. fMRI revealed decreased amygdala
activation in JME patients as compared to healthy controls. Patients
were at a higher risk of experiencing psychiatric disorders as compared
to healthy controls. Cognitive evaluation revealed impaired attentional
and executive functioning, namely psychomotor speed, tonic alertness,
divided attention, mental flexibility, and inhibition of automated
reactions. Duration of epilepsy correlated negatively with parallel
prosodic and facial emotion recognition in NEmo. Deficits in emotion
recognition were not associated with psychiatric comorbidities, impaired
attention and executive functions, types of seizures, and treatment.
Significance
This prospective study demonstrated that as compared
to healthy subjects, patients with JME had significant deficits in
recognition and perception of emotions as shown by neuropsychological
tests and fMRI. The results of this study may have importance for
psychological/psychotherapeutic interventions in the management of
patients with JME.
AB -
Objective
Perception and recognition of emotions are fundamental
prerequisites of human life. Patients with juvenile myoclonic epilepsy
(JME) may have emotional and behavioral impairments that might influence
socially desirable interactions. We aimed to investigate perception and
recognition of emotions in patients with JME by means of
neuropsychological tests and functional magnetic resonance imaging
(fMRI).
Methods
Sixty-five patients with JME (median age = 27 years,
interquartile range [IQR] = 23–34) were prospectively recruited at the
Department of Neurology, Christian Doppler University Hospital,
Paracelsus Medical University, Salzburg, Austria. Patients were compared
to 68 healthy controls (median age = 24 years, IQR = 21–31), matched
for sex, age, and education. All study participants underwent the
Networks of Emotion Processing test battery (NEmo), an fMRI paradigm of
“dynamic fearful faces,” a structured interview for psychiatric and
personality disorders, and comprehensive neuropsychological testing.
Results
JME patients versus healthy controls demonstrated
significant deficits in emotion recognition in facial and verbal tasks
of all emotions, especially fear. fMRI revealed decreased amygdala
activation in JME patients as compared to healthy controls. Patients
were at a higher risk of experiencing psychiatric disorders as compared
to healthy controls. Cognitive evaluation revealed impaired attentional
and executive functioning, namely psychomotor speed, tonic alertness,
divided attention, mental flexibility, and inhibition of automated
reactions. Duration of epilepsy correlated negatively with parallel
prosodic and facial emotion recognition in NEmo. Deficits in emotion
recognition were not associated with psychiatric comorbidities, impaired
attention and executive functions, types of seizures, and treatment.
Significance
This prospective study demonstrated that as compared
to healthy subjects, patients with JME had significant deficits in
recognition and perception of emotions as shown by neuropsychological
tests and fMRI. The results of this study may have importance for
psychological/psychotherapeutic interventions in the management of
patients with JME.
KW - JME
KW - emotion perception
KW - emotion recognition
KW - affective
KW - NEmo
UR - http://www.scopus.com/inward/record.url?scp=85174305717&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/37795683/
UR - https://www.mendeley.com/catalogue/0f91cad6-b870-3871-a6c1-f590894dc989/
U2 - 10.1111/epi.17783
DO - 10.1111/epi.17783
M3 - Article
C2 - 37795683
SN - 0013-9580
VL - 64
SP - 3319
EP - 3330
JO - Epilepsia
JF - Epilepsia
IS - 12
ER -