Reduced intrinsic neural timescales in schizophrenia along posterior parietal and occipital areas

Lavinia Carmen Uscătescu; Sarah Said-Yürekli; Lisa Kronbichler; Renate Stelzig-Schöler; Brandy-Gale Pearce; Luise Antonia Reich; Stefanie Weber; Wolfgang Aichhorn; Martin Kronbichler

doi:10.1038/s41537-021-00184-x

Reduced intrinsic neural timescales in schizophrenia along posterior parietal and occipital areas

Lavinia Carmen Uscătescu^*, Sarah Said-Yürekli, Lisa Kronbichler, Renate Stelzig-Schöler, Brandy-Gale Pearce, Luise Antonia Reich, Stefanie Weber, Wolfgang Aichhorn, Martin Kronbichler

^*Korrespondierende/r Autor/-in für diese Arbeit

Publikation: Beitrag in Fachzeitschrift › Artikel › Peer-reviewed

Abstract

We computed intrinsic neural timescales (INT) based on resting-state functional magnetic resonance imaging (rsfMRI) data of healthy controls (HC) and patients with schizophrenia spectrum disorder (SZ) from three independently collected samples. Five clusters showed decreased INT in SZ compared to HC in all three samples: right occipital fusiform gyrus (rOFG), left superior occipital gyrus (lSOG), right superior occipital gyrus (rSOG), left lateral occipital cortex (lLOC) and right postcentral gyrus (rPG). In other words, it appears that sensory information in visual and posterior parietal areas is stored for reduced lengths of time in SZ compared to HC. Finally, we found that symptom severity appears to modulate INT of these areas in SZ.

Originalsprache	Englisch
Aufsatznummer	55
Seitenumfang	8
Fachzeitschrift	npj Schizophrenia
Jahrgang	7
DOIs	https://doi.org/10.1038/s41537-021-00184-x
Publikationsstatus	Veröffentlicht - 22 Nov. 2021

Bibliographische Notiz

Funding Information:
This work was funded by the following research grants: Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung)—W1233-G17 [Uscatescu]. Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung)—P 30390-B27 [Kronbichler].

Publisher Copyright:
© 2021, The Author(s).

Systematik der Wissenschaftszweige 2012

501 Psychologie

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10.1038/s41537-021-00184-xLizenz: CC BY

Andere Dateien und Links

Investigating phenotypes of choice using comutational fMRI
Kronbichler, M. (Projektleitung)
1/10/17 → 30/09/21
Projekt: Forschung
Doktoratskolleg Imaging the Mind: Connectivity and Higher Cognitive Function
Schabus, M. (Projektleitung), Wilhelm, F. (Projektmitarbeiter/in), Hutzler, F. (Projektmitarbeiter/in), Jonas, E. (Projektmitarbeiter/in), Klimesch, W. (Projektmitarbeiter/in), Kronbichler, M. (Projektmitarbeiter/in), Perner, J. (Projektmitarbeiter/in), Pletzer, B. A. (Projektmitarbeiter/in), Aichhorn, M. (Projektmitarbeiter/in), Blechert, J. (Projektmitarbeiter/in), Heib, D. P. J. (Projektmitarbeiter/in), Hödlmoser, K. (Projektmitarbeiter/in), Klackl, J. (Projektmitarbeiter/in), Krenn, A. (Projektmitarbeiter/in) & Schurz, M. (Projektmitarbeiter/in)
1/03/15 → 28/02/19
Projekt: Forschung

Dieses zitieren

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title = "Reduced intrinsic neural timescales in schizophrenia along posterior parietal and occipital areas",

abstract = "We computed intrinsic neural timescales (INT) based on resting-state functional magnetic resonance imaging (rsfMRI) data of healthy controls (HC) and patients with schizophrenia spectrum disorder (SZ) from three independently collected samples. Five clusters showed decreased INT in SZ compared to HC in all three samples: right occipital fusiform gyrus (rOFG), left superior occipital gyrus (lSOG), right superior occipital gyrus (rSOG), left lateral occipital cortex (lLOC) and right postcentral gyrus (rPG). In other words, it appears that sensory information in visual and posterior parietal areas is stored for reduced lengths of time in SZ compared to HC. Finally, we found that symptom severity appears to modulate INT of these areas in SZ.",

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doi = "10.1038/s41537-021-00184-x",

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AU - Uscătescu, Lavinia Carmen

AU - Said-Yürekli, Sarah

AU - Kronbichler, Lisa

AU - Stelzig-Schöler, Renate

AU - Pearce, Brandy-Gale

AU - Reich, Luise Antonia

AU - Weber, Stefanie

AU - Aichhorn, Wolfgang

AU - Kronbichler, Martin

PY - 2021/11/22

Y1 - 2021/11/22

N2 - We computed intrinsic neural timescales (INT) based on resting-state functional magnetic resonance imaging (rsfMRI) data of healthy controls (HC) and patients with schizophrenia spectrum disorder (SZ) from three independently collected samples. Five clusters showed decreased INT in SZ compared to HC in all three samples: right occipital fusiform gyrus (rOFG), left superior occipital gyrus (lSOG), right superior occipital gyrus (rSOG), left lateral occipital cortex (lLOC) and right postcentral gyrus (rPG). In other words, it appears that sensory information in visual and posterior parietal areas is stored for reduced lengths of time in SZ compared to HC. Finally, we found that symptom severity appears to modulate INT of these areas in SZ.

AB - We computed intrinsic neural timescales (INT) based on resting-state functional magnetic resonance imaging (rsfMRI) data of healthy controls (HC) and patients with schizophrenia spectrum disorder (SZ) from three independently collected samples. Five clusters showed decreased INT in SZ compared to HC in all three samples: right occipital fusiform gyrus (rOFG), left superior occipital gyrus (lSOG), right superior occipital gyrus (rSOG), left lateral occipital cortex (lLOC) and right postcentral gyrus (rPG). In other words, it appears that sensory information in visual and posterior parietal areas is stored for reduced lengths of time in SZ compared to HC. Finally, we found that symptom severity appears to modulate INT of these areas in SZ.

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Reduced intrinsic neural timescales in schizophrenia along posterior parietal and occipital areas

Abstract

Bibliographische Notiz

Systematik der Wissenschaftszweige 2012

Zugriff auf Dokument

Andere Dateien und Links

Projekte

Investigating phenotypes of choice using comutational fMRI

Doktoratskolleg Imaging the Mind: Connectivity and Higher Cognitive Function

Dieses zitieren