Innate immune memory in Helicobacter pylori infection

Description

Immune responses against H. pylori often prove ineffective in eradicating the pathogen, paradoxically contributing to epithelial degeneration and disease progression. Various scientific advances have shown that H. pylori infection has profound effects on peripheral adaptive immune memory responses. The formation of innate immune memory in response to H. pylori and its influence on innate immune function, on the other hand, has only been sparsely investigated. In this regard we show that while other bacterial stimuli, such as E. coli LPS or the gram-negative bacterium Acinetobacter lwoffii, induce tolerance to repeated encounters, H. pylori infection of primary human monocytes enhances their responsiveness to subsequent bacterial stimuli. Moreover, we show that H. pylori priming establishes a distinctive proteomic signature, with accumulation of NF-кB proteins playing a major role in enhancing the responsiveness of monocytes to subsequent LPS challenge. Thus, plasticity of proinflammatory responses, modulated by the abundance and availability of intracellular signaling molecules, emerges as a novel aspect of the pathobiology induced by H. pylori.

Period	2 Dec 2023 → 5 Dec 2023
Event title	Helicobacter pylori: genomics, signaling and carcinogenesis conference (HGSC 2023)
Event type	Conference
Location	Beilngries, Germany, BavariaShow on map
Degree of Recognition	International