Projects per year
Personal profile
Research interests
Driven by the question how malignant hematopoietic cells occupy and modify bone marrow niches to establish a tumor protecting and promoting microenvironment, integrin-mediated leukemic cell adhesion and signaling have been the focus of my research.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 2 Active
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TARGET MPN: Targeting Kindlin-3-mediated integrin activation and signaling to eradicate persistent MPN clones
Krenn, P. (Principal Investigator) & Lankes, D. (Co-Investigator)
1/07/24 → 30/06/28
Project: Research
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Novel Inhibitors: Novel Inhibitors targeting oncogenic Hedgehog/GLI signaling
Aberger, F. (Principal Investigator), Krenn, P. (Co-Investigator) & Aichberger, S. K. (Co-Investigator)
1/09/23 → 31/12/24
Project: Research
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ADP-heptose attenuates Helicobacter pylori-induced dendritic cell activation
Neuper, T., Frauenlob, T., Dang, H.-H., Krenn, P. W., Posselt, G., Regl, C., Fortelny, N., Schäpertöns, V., Unger, M. S., Üblagger, G., Neureiter, D., Mühlbacher, I., Weitzendorfer, M., Singhartinger, F., Emmanuel, K., Huber, C. G., Wessler, S., Aberger, F. & Horejs-Hoeck, J., 17 Sept 2024, In: Gut Microbes. 16, 1, p. 2402543Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting NLRP3 inhibits AML progression by inducing PERK/eIF2-mediated apoptosis
Luciano, M., Sieberer, H., Krenn, P. W., Dang, H.-H., Vetter, J., Neuper, T., Amend, D., Blöchl, C., Weichenberger, C. X., Eglseer, A., Unger, M. S., Andosch, A., Steiner, P., Neureiter, D., Bauer, R., Hummer, L., Tesanovic, S., Binder, S., Elmer, D. P. & Strandt, H. & 10 others, , 2 Sept 2024, In: Cell Communication and Signaling. 22, 1, p. 424 424.Research output: Contribution to journal › Article › peer-review
Open Access -
Hedgehog-Hippo pathway interactions promote T cell exclusion from the tumor microenvironment in basal cell carcinoma
Stockmaier, G., Varkhande, S., Krenn, P., Dang, H.-H., Sharma, A., Elmer, D. P., Steiner, M., Zaborsky, N., Neureiter, D., Greil, R., Horejs-Hoeck, J., Fortelny, N. & Aberger, F., 2024, bioRxiv.Research output: Working paper/Preprint › Preprint
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Targeting cancer hallmark vulnerabilities in hematologic malignancies by interfering with Hedgehog/GLI signaling
Krenn, P. W. & Aberger, F., 7 Dec 2023, In: BLOOD. 142, 23, p. 1945-1959 15 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
The Class IIA Histone Deacetylase (HDAC) Inhibitor TMP269 Downregulates Ribosomal Proteins and Has Anti-Proliferative and Pro-Apoptotic Effects on AML Cells
Urwanisch, L., Unger, M. S., Sieberer, H., Dang, H.-H., Neuper, T., Regl, C., Vetter, J., Schaller, S., Winkler, S. M., Kerschbamer, E., Weichenberger, C. X., Krenn, P. W., Luciano, M., Pleyer, L., Greil, R., Huber, C. G., Aberger, F. & Horejs-Hoeck, J., 7 Feb 2023, In: Cancers. 15, 4, 1039.Research output: Contribution to journal › Article › peer-review
Open Access
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GLI-YAP interactions in basal cell carcinoma promote immune evasion by regulating the spatial distribution of immune responses.
Krenn, P. (Speaker), Stockmaier, G. (Speaker), Varkhande, S. (Speaker), Dang, H.-H. (Speaker), Sharma, A. (Speaker), Elmer, D. P. (Speaker), Steiner, M. (Speaker), Zaborsky, N. (Speaker), Neureiter, D. (Speaker), Greil, R. (Speaker), Horejs-Höck, J. (Speaker), Fortelny, N. (Speaker), Gratz, I. K. (Speaker) & Aberger, F. (Speaker)
12 Dec 2024Activity: Talk or presentation › Poster presentation › science to science / art to art
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Characterizing and disrupting leukemic stem cell interactions with their supportive microenvironment
Krenn, P. (Speaker)
29 Nov 2024Activity: Talk or presentation › Oral presentation › science to science / art to art
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ADP-heptose attenuates H. pylori-induced DC activation
Neuper, T. (Speaker), Frauenlob, T. (Speaker), Dang, H.-H. (Speaker), Krenn, P. (Speaker), Posselt, G. B. (Speaker), Regl, C. (Speaker), Fortelny, N. (Speaker), Schäpertöns, V. (Speaker), Unger, M. S. (Speaker), Üblagger, G. L. (Speaker), Neureiter, D. (Speaker), Mühlbacher, I. (Speaker), Weitzendorfer, M. (Speaker), Singhartinger, F. (Speaker), Emmanuel, K. (Speaker), Huber, C. (Speaker), Weßler, S. (Speaker), Aberger, F. (Speaker) & Horejs-Höck, J. (Speaker)
3 Jul 2024 → 6 Jul 2024Activity: Talk or presentation › Poster presentation › science to science / art to art
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Effects of ADP-heptose on human primary dendritic cells
Neuper, T. (Speaker), Frauenlob, T. (Speaker), Dang, H.-H. (Speaker), Posselt, G. B. (Speaker), Regl, C. (Speaker), Krenn, P. (Speaker), Unger, M. S. (Speaker), Huber, C. (Speaker), Aberger, F. (Speaker), Fortelny, N. (Speaker), Weßler, S. (Speaker) & Horejs-Höck, J. (Speaker)
2 Dec 2023 → 5 Dec 2023Activity: Talk or presentation › Oral presentation › science to science / art to art
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Deciphering the regulation and function of integrin activators Kindlin-3 and Talin-1 in leukemic (stem) cells using in vitro and in vivo models
Lankes, D. (Speaker), Doma, E. (Speaker), Mayer, L. (Speaker), Sexl, V. (Speaker), Koschmieder, S. (Speaker), Aberger, F. (Speaker) & Krenn, P. (Speaker)
20 Sept 2023Activity: Talk or presentation › Poster presentation › science to science / art to art