Feasibility study on effects by detergents/additives on physico-chemical characterization of therapeutic proteins

    Project Details

    Description

    State-of-the-art physicochemical characterization techniques for therapeutic proteins were tested for their applicability in presence of detergents at concentrations below of, equal to, and above from critical micellar concentration (CMC) of detergents. Consulting on detergents and additives suitable for use in biological therapeutics was provided.

    A number of candidate detergents to be used as additives for better solubility of easily aggregating therapeutic proteins were investigated in termes of influence on physico-chemical characterization methods.
    Short titleDetergent effects on PC protein charaterization
    StatusFinished
    Effective start/end date1/06/12 → 31/01/13

    Fields of Science and Technology Classification 2002

    • 3314 Vaccine development
    • 3313 Pharmaceutical and drug analysis
    • 1402 Biochemistry