Regulation of cutaneous tissue-repair by a specialized population of CD4+ T cells

    Project Details

    Description

    In healthy individuals T cells in the skin not only combat infection but also work in concert to help maintain normal tissue homeostasis and promote wound repair. We have identified a novel population of CLA+CD4+ T cells in the peripheral blood of healthy subjects, and we hypothesize that this is a regulatory population of skin-tropic T cells that participates in the wound healing response. In this proposal, we will use in vitro analyses and innovative humanized mouse models to test this hypothesis, assessing the developmental origins of CLA+CD103+ cells, examining their antigen-specificity, and determining their function during cutaneous inflammation and wound healing.

    In this proposal, we will use in vitro analyses and innovative humanized mouse models to test this hypothesis, assessing the developmental origins of CD103+CLAhi cells, examining their antigen-specificity, and determining their function during cutaneous wound healing.

    Specific Aim 1 – Determine the developmental relationship of CD103+CLAhicells with T cell populations in the skin, and examine the molecular requirements for CD103+CLAhi cell differentiation. Specific Aim 2 – Assess the antigen-specificity of CD103+CLAhicells Specific Aim 3 – Determine the function of CD103+CLAhicells using humanized mouse models of cutaneous wound healing.
    Short titleNIH – wound healing
    StatusActive
    Effective start/end date20/06/1719/06/22

    Fields of Science and Technology Classification 2012

    • 302 Clinical Medicine
    • 301 Medical-Theoretical Sciences, Pharmacy
    • 106 Biology

    Fields of Science and Technology Classification 2002

    • 3411 Immunology
    • 1409 Human biology
    • 3508 Dermatology
    • 1411 Molecular biology

    Fields of Science and Technology Classification 2012 (6-digit codes)

    • 106018 Human biology
    • 301902 Immunology
    • 302011 Dermatology
    • 106023 Molecular biology