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  • Peter Lackner
  • Josef Laimer
  • Markus Wiederstein
2020

A hybrid of two major Blomia tropicalis allergens as an allergy vaccine candidate

da Silva, E. S., Aglas, L., Pinheiro, C. S., de Andrade Belitardo, E. M. M., Silveira, E. F., Huber, S., Torres, R. T., Wallner, M., Briza, P., Lackner, P., Laimer, J., Pacheco, L. G. C., Cruz, Á. A., Alcântara-Neves, N. M. & Ferreira, F., 1 Jul 2020, In : Clinical and Experimental Allergy. 50, 7, p. 835-847 13 p.

Research output: Contribution to journalArticle

Retinoic acid-loading of the major birch pollen allergen Bet v 1 may improve specific allergen immunotherapy: In silico, in vitro and in vivo data in BALB/c mice

Hufnagl, K., Afify, S. M., Braun, N., Wagner, S., Wallner, M., Hauser, M., Wiederstein, M., Gadermaier, G., Wildner, S., Redegeld, F. A., Blokhuis, B. R., Hofstetter, G., Pali-Schoell, I., Roth-Walter, F., Pacios, L. F. & Jensen-Jarolim, E., 16 Apr 2020, In : Allergy: European Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalLetter

Open Access
Open Access
2019

Binding of vitamin D3 to the major birch pollen allergen Bet v 1 attenuates its allergenic capacity

Hufnagl, K., Kromp, L., Bianchini, R., Wiederstein, M., Redegeld, F., Hofstetter, G., Roth-Walter, F., F.Pacios, L. & Jensen-Jarolim, E., 2019.

Research output: Contribution to conferencePoster

Compound heterozygous SZT2 mutations in two siblings with early-onset epilepsy, intellectual disability and macrocephaly

Domingues, F. S., König, E., Schwienbacher, C., Volpato, C. B., Picard, A., Cantaloni, C., Mascalzoni, D., Lackner, P., Heimbach, A., Hoffmann, P., Stanzial, F., Hicks, A. A., Parmeggiani, L., Benedicenti, F., Pellegrin, S., Casara, G. & Pramstaller, P. P., Mar 2019, In : Seizure : the journal of the British Epilepsy Association. 66, p. 81-85 5 p.

Research output: Contribution to journalArticle

Open Access

Rational Design, Structure-Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants

Eichhorn, S., Hörschläger, A., Steiner, M., Laimer, J., Jensen, B. M., Versteeg, S. A., Pablos, I., Briza, P., Jongejan, L., Rigby, N., Asturias, J. A., Portolés, A., Fernandez-Rivas, M., Papadopoulos, N. G., Mari, A., Poulsen, L. K., Lackner, P., van Ree, R., Ferreira, F. & Gadermaier, G., Sep 2019, In : Molecular Nutrition and Food Research. 63, 18, p. 1-10 1900336.

Research output: Contribution to journalArticle

Open Access

Retinoic acid determines the allergenicity of the major birch pollen allergen Bet v 1 in vitro and in vivo

Hufnagl, K., Afify, S., Braun, N., Wagner, S., Wiederstein, M., Hofstetter, G., Pali-Schoell, I., Roth-Walter, F., Pacios, L. F. & Jensen-Jarolim, E., Aug 2019, In : Allergy: European Journal of Allergy and Clinical Immunology. 74, p. 335-336

Research output: Contribution to journalMeeting Abstract

Structure Based Prediction of MHC II Binding Peptides

Laimer, J., Wiederstein, M. & Lackner, P., 22 Jul 2019.

Research output: Contribution to conferencePoster

The cell wall PAC (Pro-rich, Arabinogalactan proteins, conserved Cysteines) domain-proteins are conserved in the green lineage

Nguyen-Kim, H., San Clemente, H., Kolkas, H., Laimer, J., Lackner, P., Gadermaier, G., Dunand, C. & Jamet, E., 2019.

Research output: Contribution to conferenceAbstract

Synergistic cross-talk of hedgehog and interleukin-6 signaling drives growth of basal cell carcinoma

Sternberg, C., Gruber, W., Eberl, M., Tesanovic, S., Stadler, M., Elmer, D. P., Schlederer, M., Grund, S., Roos, S., Wolff, F., Kaur, S., Mangelberger, D., Lehrach, H., Hache, H., Wierling, C., Laimer, J., Lackner, P., Wiederstein, M., Kasper, M., Risch, A. & 4 others, Petzelbauer, P., Moriggl, R., Kenner, L. & Aberger, F., 1 Dec 2018, In : International Journal of Cancer. 143, 11, p. 2943-2954

Research output: Contribution to journalArticle

The pollen plasma membrane permeome converts transmembrane ion transport into speed

Pertl-Obermeyer, H., Lackner, P., Dunlop, J. & Obermeyer, G., 2018, In : ADVANCES IN BOTANICAL RESEARCH.

Research output: Contribution to journalArticle

2017

Allergens of Blomia tropicalis: An Overview of Recombinant Molecules

Santos Da Silva, E., Asam, C., Lackner, P., Hofer, H., Wallner, M., Silva Pinheiro, C., Alcântara-Neves, N. M. & Ferreira, F., 2017, In : International Archives of Allergy and Immunology. 172, 4, p. 203-214

Research output: Contribution to journalReview article

Characterization of a Phl p 6 mutant with increased structural stability

Soh, W. T., Stubenvoll, S., Brückl, A., Scheiblhofer, S., Laimer, J., Lackner, P., Thalhamer, J., Brandstetter, H. & Weiss, R., 17 Jun 2017.

Research output: Contribution to conferencePoster

Identification of proteases and protease inhibitors in allergenic and non-allergenic pollen

Höllbacher, B., Schmitt, A. O., Hofer, H., Ferreira, F. & Lackner, P., 2017, In : International Journal of Molecular Sciences. 18, 6, 1199.

Research output: Contribution to journalArticle

Influence of protein fold stability on immunogenicity and its implications for vaccine design

Scheiblhofer, S., Laimer, J., Hernandez, Y. J. M., Weiss, R. & Thalhamer, J., 2017, In : Expert Review of Vaccines.

Research output: Contribution to journalArticle

Influence of protein fold stability on immunogenicity and its implications for vaccine design

Scheiblhofer, S., Laimer, J., Machado, Y., Weiss, R. & Thalhamer, J., 2017, In : Expert Review of Vaccines. 16, 5, p. 479-489

Research output: Contribution to journalReview article

Multi-approach analysis for the identification of proteases within birch pollen

McKenna, O. E., Posselt, G. B., Briza, P., Lackner, P., Schmitt, A. O., Gadermaier, G., Weßler, S. & Ferreira, F., 2017, In : International Journal of Molecular Sciences. 18, 7, 1433.

Research output: Contribution to journalArticle

Tackling Bet v 1 and associated food allergies with a single hybrid protein

Hofer, H., Asam, C., Hauser, M., Nagl, B., Laimer, J., Himly, M., Briza, P., Ebner, C., Lang, R., Hawranek, T., Bohle, B., Lackner, P., Ferreira, F. & Wallner, M., 2017, In : Journal of Allergy and Clinical Immunology. 140, 2, p. 525-533

Research output: Contribution to journalArticle

2016

Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen

Machado, Y., Freier, R., Scheiblhofer, S., Thalhamer, T., Mayr, M., Briza, P., Grutsch, S., Ahammer, L., Fuchs, J. E., Wallnoefer, H. G., Isakovic, A., Kohlbauer, V., Hinterholzer, A., Steiner, M., Danzer, M., Horejs-Höck, J., Ferreira, F., Liedl, K. R., Tollinger, M., Lackner, P. & 4 others, Johnson, C. M., Brandstetter, J., Thalhamer, J. & Weiss, R., May 2016, In : Journal of Allergy and Clinical Immunology. 137, 5, p. 1525-1534 10 p.

Research output: Contribution to journalArticle

Open Access

MAESTROweb: a web server for structure based protein stability prediction: a web server for structure-based protein stability prediction

Laimer, J., Hiebl-Flach, J., Lengauer, D. & Lackner, P., 1 May 2016, In : Bioinformatics. 32, 9, p. 1414-6 3 p.

Research output: Contribution to journalArticle

Open Access

Nanoparticle-allergen interactions mediate human allergic responses: Protein corona characterization and cellular responses: protein corona characterization and cellular responses

Radauer-Preiml, I., Andosch, A., Hawranek, T., Lütz-Meindl, U., Wiederstein, M., Horejs-Höck, J., Himly, M., Boyles, M. & Duschl, A., 16 Jan 2016, In : Particle and Fibre Toxicology. 13, 1, p. 1-15 3.

Research output: Contribution to journalArticle

Open Access

The Hyper-Allergenic Isoform Bet v 1a of the Major Birch Pollen Allergen Displays Reduced Allergenic Potential after Binding of Retinoic Acid

Hufnagl, K., Wagner, S., F.Pacios, L., Wallner, M., Wiederstein, M., Hofstetter, G., Roth-Walter, F. & Jensen-Jarolim, E., 2016.

Research output: Contribution to conferencePoster

2015

MAESTRO - multi agent stability prediction upon point mutations

Laimer, J., Hofer, H., Fritz, M., Wegenkittl, S. & Lackner, P., 16 Apr 2015, In : BMC Bioinformatics. 16, p. 1-13 13 p., 116.

Research output: Contribution to journalArticle

Open Access

Nanoparticle-allergen interactions mediate human allergic responses: protein corona characterization and cellular responses

Radauer-Preiml, I., Andosch, A., Hawranek, T., Luetz-Meindl, U., Wiederstein, M., Horejs-Hoeck, J., Himly, M., Boyles, M. S. P. & Duschl, A., 2015, In : Particle and Fibre Toxicology.

Research output: Contribution to journalArticle

2014

Differences in the intrinsic immunogenicity and allergenicity of Bet v 1 and related food allergens revealed by site-directed mutagenesis

Roulias, A., Pichler, U., Hauser, M., Himly, M., Hofer, H., Lackner, P., Ebner, C., Briza, P., Bohle, B., Egger, M., Wallner, M. & Ferreira, F., 2014, In : ALLERGY. p. 208-15

Research output: Contribution to journalArticle

Immunological characterization of a Pru p 3 proline variant for treatment of LTP-related peach allergy

Gadermaier, G., Laimer, J., Ocampo, I. M. P., Eichhorn, S. P. & Ferreira, F., 2014.

Research output: Contribution to conferenceAbstract

Pru p 3 mimicks

Gadermaier, G., Wallner, M., Lackner, P. & Ferreira, F., 17 Dec 2014, Patent No. 2813243, 14 Aug 2013, Priority No. 13171445.3 - 1412

Research output: Patent

Structure-Based Characterization of Multiprotein Complexes

Wiederstein, M., Gruber, M., Frank, K., Melo, F. & Sippl, M. J., 8 Jul 2014, In : Structure. 22, 7, p. 1063-1070 8 p.

Research output: Contribution to journalArticle

2013

Automated clustering of protein structures and complexes

J.Sippl, M., Frank, K., Gruber, M. & Wiederstein, M., 2013.

Research output: Contribution to conferencePoster

Comprehensive analysis of alterations in the miRNome in response to photodynamic treatment

Bach, D., Fuereder, J., Karbiener, M., Scheideler, M., Lena, R. A., Neureiter, D., Kemmerling, R., Dietze, O., Wiederstein, M., Berr, F., Plätzer, K., Kiesslich, T. & Pichler, M., 5 Mar 2013, In : Journal of Photochemistry and Photobiology B: Biology. 120, p. 74-81 8 p.

Research output: Contribution to journalArticle

Development of a hypoallergenic and immunogenic Pru p 3 proline variant for treatment of peach allergy

Eichhorn, S. P., Steiner, M., Laimer, J., Lackner, P., Zuidmeer-Jongejan, L., Briza, P., Mari, A., Ree, R. V., Ferreira, F. & Gadermaier, G., 2013.

Research output: Contribution to conferenceAbstract

D-Light on promoters: a client-server system for the analysis and visualization of cis-regulatory elements

Laimer, J., Zuzan, C. J., Ehrenberger, T., Freudenberger, M., Gschwandtner, S., Lebherz, C. & Lackner, P., 24 Apr 2013, In : BMC Bioinformatics. 14, p. 1-8 140.

Research output: Contribution to journalArticle

Open Access

Structural and functional collection of biological units

J.Sippl, M., Frank, K., Wiederstein, M. & Gruber, M., 2013.

Research output: Contribution to conferencePoster

2012

Detection of spatial correlations in protein structures and molecular complexes

Sippl, M. J. & Wiederstein, M., 4 Apr 2012, In : Structure. 20, 4, p. 718-728 11 p.

Research output: Contribution to journalArticle

Effective techniques for protein structure mining

Suhrer, S. J., Gruber, M., Wiederstein, M. & Sippl, M. J., 2012, In : Methods in molecular biology (Clifton, N.J.). 857, p. 33-54 22 p.

Research output: Contribution to journalArticle

Nitration of the pollen allergen bet v 1.0101 enhances the presentation of bet v 1-derived peptides by HLA-DR on human dendritic cells

Karle, AC., Oostingh, GJ., Mutschlechner, S., Ferreira, F., Lackner, P., Bohle, B., Fischer, GF., Vogt, AB. & Duschl, A., 2012, In : PLOS one.

Research output: Contribution to journalArticle

2011

Leben nach Plan - Utopien in den Biowissenschaften

Translated title of the contribution: Leben nach Plan - Utopien in den BiowissenschaftenWiederstein, M., 2011, Europäische Projektkultur als Beitrag zur Rationalisierung des Rechts. ÖCG, p. 613-618 (Tagungsband des Internationalen Rechtsinformatik Symposions IRIS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2010

Designing hypoallergenic derivatives for allergy treatment by means of in silico mutation and screening

Thalhamer, T., Dobias, H., Stepanoska, T., Pröll, M., Stutz, E-H., Dissertori, O., Lackner, P., Ferreira, F., Wallner, M., Thalhamer, J. & Hartl, A. J., 2010, In : Journal of Allergy and Clinical Immunology. p. 926-934

Research output: Contribution to journalArticle

2009

Accuracy analysis of multiple structure alignments

Berbalk, C., Schwaiger, CS. & Lackner, P., 2009, In : Protein Science. p. 2027-35

Research output: Contribution to journalArticle

COPS--a novel workbench for explorations in fold space

Suhrer, S. J., Wiederstein, M., Gruber, M. & Sippl, M. J., Jul 2009, In : Nucleic Acids Research. 37, Web Server issue, p. W539-44

Research output: Contribution to journalArticle

COPS—a novel workbench for explorations in fold space

Suhrer, S., Wiederstein, M., Gruber, M. & Sippl, M. J., 2009, In : Nucleic Acids Research. p. W539-W544

Research output: Contribution to journalArticle

Identification of B-cell epitopes of Bet v 1 involved in cross-reactivity with food allergens

Klinglmayr, E., Hauser, M., Zimmermann, F., Dissertori, O., Lackner, P., Wopfner, N., Ferreira, F. & Wallner, M., 2009, In : ALLERGY. p. 647-651

Research output: Contribution to journalArticle

Structural diversity of calcium binding sites

Bindreither, D. & Lackner, P., 2009, In : General physiology and biophysics. p. F82-F88

Research output: Contribution to journalArticle

The vacuolar serine protease, a cross-reactive allergen from cladiosporum herbarum

Pöll, V., Denk, U., Shen, HD., Panzani, RC., Dissertori, O., Lackner, P., Hemmer, W., Mari, A., Crameri, R., Lottspeich, F., Rid, R., Richter, K., Breitenbach, M. & Simon-Nobbe, B., 2009, In : Molecular immunology.

Research output: Contribution to journalArticle

The vacuolar serine protease, a cross-reactive allergen from Cladosporium herbarum

Pöll, V., Denk, U., Shen, H-D., C.Panzani, R., Dissertori, O., Lackner, P., Hemmer, W., Mari, A., Crameri, R., Lottspeich, F., Rid, R., Richter, K., Breitenbach, M. & Simon-Nobbe, B., 2009, In : Molecular immunology. p. 1360-1373 14 p.

Research output: Contribution to journalArticle

2008

A Discrete View on Fold Space

Sippl, M. J., Suhrer, S. J., Gruber, M., Wiederstein, M. & Suhrer, S., 15 Mar 2008, In : Bioinformatics. 24, 6, p. 870-871 2 p.

Research output: Contribution to journalArticle

A note on difficult structure alignment problems

Sippl, M. J. & Wiederstein, M., 1 Feb 2008, In : Bioinformatics. 24, 3, p. 426-7 2 p.

Research output: Contribution to journalArticle

Automated Quantitative Assessment of Proteins' Biological Function in Protein Knowledge Bases

Mayr, G., Lepperdinger, G. & Lackner, P., 2008, In : Advances in Bioinformatics. 2008, 7 p.

Research output: Contribution to journalArticle

Generation of a hypoallergenic Bet v 1 derivative by epitope grafting

Hauser, M., Wallner, M., Klinglmayr, E., Gadermaier, G., Wopfner, N., Vogel, L., Lackner, P., Bohle, B. & Ferreira, F., 2008.

Research output: Contribution to conferenceAbstract

The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands

Radauer, C., Lackner, P. & Breiteneder, H., 2008, In : BMC Evolutionary Biology. 19 p.

Research output: Contribution to journalArticle

2007

Allergy multi-vaccines created by DNA shuffling of tree pollen allergens

Wallner, M., Stöcklinger, A., Thalhamer, T., Bohle, B., Vogel, L., Ferreira, F., Breiteneder, H., Vieths, S., Hartl, A., Mari, A., Ebner, C., Lackner, P., Hammerl, P., Thalhamer, J. & Ferreira, F., 2007, In : Journal of Allergy and Clinical Immunology. p. 374-380

Research output: Contribution to journalArticle

Calcium-binding proteins and their role in allergic diseases

Wopfner, N., Dissertori, O., Ferreira, F. & Lackner, P., 2007, In : Immunol Allergy Clin North Am. p. 117-20

Research output: Contribution to journalReview article

Calcium-binding proteins and their role in allergic diseases

Wopfner, N., Dissertori, O., Ferreira, F. & Lackner, P., 2007, In : Immunol Allergy Clin North Am. p. 29-44

Research output: Contribution to journalReview article

Comparative analysis of protein structure alignments

Mayr, G., Domingues, FS. & Lackner, P., 2007, In : BMC STRUCTURAL BIOLOGY.

Research output: Contribution to journalArticle

ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins

Wiederstein, M. & Sippl, M. J., 2007, In : Nucleic Acids Research. p. W407-W410

Research output: Contribution to journalArticle

QSCOP - SCOP quantified by structural relationships

Suhrer, S. J., Wiederstein, M. & Sippl, M. J., 15 Feb 2007, In : Bioinformatics. 23, 4, p. 513-514 2 p.

Research output: Contribution to journalArticle

2005

Pathogenic mutations inactivate parkin by distinct mechanisms

Henn, IH., Gostner, JM., Lackner, P., Tatzelt, J. & Winklhofer, KF., 2005, In : Journal of Neurochemistry. p. 114-122

Research output: Contribution to journalArticle

Protein sequence randomization: efficient estimation of protein stability using knowledge-based potentials

Wiederstein, M. & Sippl, M. J., 4 Feb 2005, In : Journal of Molecular Biology. 345, 5, p. 1199-1212 13 p.

Research output: Contribution to journalArticle

2004

Directed in silico Mutagenesis

Wiederstein, M., Lackner, P., Kienberger, F. & Sippl, M. J., 2004, Evolutionary Methods in Biotechnology. Wiley-VCH, p. 153-175 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in Book

WILMA-automated annotation of protein sequences

Prlic, A., Domingues, FS., Lackner, P. & Sippl, MJ., 2004, In : Bioinformatics. p. 127-128

Research output: Contribution to journalArticle

2003

ProMine: Identification of Protein Family Members Using Profiles Derived From Multiple Structure Alignments

Prlic, A., Lackner, P. & Sippl, M. J., 2003, 1 p.

Research output: Other contributionResearchpeer-review

ProSupSpace - a Webservice to Search the SCOP Classification for Similar Structures

Suhrer, S., Prlic, A., Leong, J., Sippl, M. J. & Lackner, P., 2003, 1 p.

Research output: Other contributionResearchpeer-review

2002

Gene Expression Profiling of Cold Ischemia/Reperfusion (I/R) Injury in Murine Cardiac Isografts

Schneeberger, S., Mark, W., Brandacher, G., Obrist, P., Lackner, P., Hernegger, G., Meusburger, H., Renz, O., Margreiter, R. & Amberger, A., 2002. 1 p.

Research output: Contribution to conferenceAbstract

Gene expression profiling of prolonged cold ischemia and reperfusion in murine heart transplants

Amberger, A., Schneeberger, S., Hernegger, G., Brandacher, G., Obrist, P., Lackner, P., Margreiter, R. & Mark, W., 2002, In : Transplantation. 74, 10, p. 1441-1449 9 p.

Research output: Contribution to journalArticle

2001

Assessment of the CASP4 Fold Recognition Category

Sippl, M. J., Lackner, P., Domingues, F. S., Prlic, A., Malik, R., Andreeva, A. & Wiederstein, M., 2001, In : Proteins: Structure, Function and Genetics. p. 55-67 13 p.

Research output: Contribution to journalArticle

Wilma, a platform for the annotation of C.elegans proteins

Prlic, A., Domingues, F. S., Lackner, P. & Sippl, M. J., 2001. 1 p.

Research output: Contribution to conferenceAbstract

2000

Characterization of novel proteins based on known protein structures

Koppensteiner, W. A., Lackner, P., Wiederstein, M. & Sippl, M. J., 3 Mar 2000, In : Journal of Molecular Biology. 296, 4, p. 1139-1152 14 p.

Research output: Contribution to journalArticle

Evaluation of Structural Models of Proteins Using Neural Networks

Benhabilès, N., Lackner, P., Domingues, F. S., Wegenkittl, S. & Sippl, M. J., 2000.

Research output: Contribution to conferenceAbstract

Evaluation of Structural Models of Proteins Using Neural Networks

Benhabilès, N., Lackner, P., Domingues, F. S., Wegenkittl, S. & Sippl, M. J., 2000.

Research output: Contribution to conferenceAbstract

1999

Automated Large Scale Evaluation of Protein Structure Predictions

Lackner, P., Koppensteiner, W. A., Domingues, F. S. & Sippl, M. J., 1999, In : Proteins: Structure, Function and Genetics. 37, 53, p. 7-14

Research output: Contribution to journalArticle

CASP3 prediction results for the fold recognition tool ProFIT

Wiederstein, M., Domingues, F. S., Koppensteiner, W. A., Jaritz, M., Prlic, A., Weichenberger, C., Flöckner, H., Lackner, P. & Sippl, M. J., 1999.

Research output: Contribution to conferencePoster

Strategy for an Automated Evaluation of Protein Structure Predictions

Lackner, P., Koppensteiner, W. A., Domingues, F. S. & Sippl, M. J., 1999.

Research output: Contribution to conferenceAbstract

Sustained Performance of Knowledge-Based Potentials in Fold Recognition

Domingues, F. S., Koppensteiner, W. A., Jaritz, M., Prlic, A., Weichenberger, C., Wiederstein, M., Flöckner, H., Lackner, P. & Sippl, M. J., 1999, In : Proteins: Structure, Function and Genetics. p. 112-120

Research output: Contribution to journalArticle

The coverage of protein fold recognition

Koppensteiner, W. A., Wiederstein, M., Lackner, P. & Sippl, M. J., 1999.

Research output: Contribution to conferencePoster