Activation of a Ductal-to-Endocrine Transdifferentiation Transcriptional Program in the Pancreatic Cancer Cell Line PANC-1 Is Controlled by RAC1 and RAC1b through Antagonistic Regulation of Stemness Factors

Paula Marie Schmidtlein, Clara Volz, Alexander Hackel, Isabel Thürling, Darko Castven, Rüdiger Braun, Ulrich Friedrich Wellner, Björn Konukiewitz, Gabriela Riemekasten, Hendrik Lehnert, Jens-Uwe Marquardt, Hendrik Ungefroren

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article number5541
Number of pages18
JournalCancers
Volume13
Issue number21
DOIs
Publication statusPublished - 4 Nov 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Ductal-to-endocrine transdifferentiation
  • PANC-1
  • Pancreatic ductal adenocarcinoma
  • Pancreatic β cell
  • Pluripotency
  • Quasimesenchymal
  • RAC1
  • RAC1b
  • SOX2
  • Stemness

Fields of Science and Technology Classification 2012

  • 302 Clinical Medicine

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