Allergens of Blomia tropicalis: An Overview of Recombinant Molecules

E Santos Da Silva, Claudia Asam, Peter Lackner, Heidi Hofer, Michael Wallner, C Silva Pinheiro, N.M Alcântara-Neves, Fatima Ferreira

Research output: Contribution to journalReview article

Abstract

Allergic diseases are considered a major problem for healthcare systems in both developed and developing countries. House dust mites are well-known triggers of allergic manifestations. While the Dermatophagoides genus is widely distributed globally, Blomia tropicalis is the most prominent mite species in the tropical and subtropical regions of the world. Over the last decades, an increase in sensitization rates to B. tropicalis has been reported, leading to increased research efforts on Blomia allergens. In fact, 8 new allergens have been identified and characterized to different degrees. Here, we provide an overview of recent developments concerning the identification and production of recombinant Blomia allergens, as well as their structural and immunological characterization. Although considerable progress has been achieved, detailed molecule-based studies are still needed to better define the clinical relevance of Blomia allergens. Thus, the establishment of a well-standardized and fully characterized panel of allergens remains a challenge for the development of better diagnosis and therapy of allergic diseases induced by B. tropicalis. © 2017 The Author(s).
Translated title of the contributionAllergens of Blomia tropicalis: An Overview of Recombinant Molecules
Original languageEnglish
Pages (from-to)203-214
JournalInternational Archives of Allergy and Immunology
Volume172
Issue number4
DOIs
Publication statusPublished - 2017

Fields of Science and Technology Classification 2012

  • 302 Clinical Medicine

Keywords

  • Blomia tropicalis
  • Cross-reactivity
  • Immunoglobulin E epitopes
  • Recombinant allergens
  • Secondary structure
  • T-cell epitopes
  • Three-dimensional structure

Cite this

Santos Da Silva, E., Asam, C., Lackner, P., Hofer, H., Wallner, M., Silva Pinheiro, C., Alcântara-Neves, N. M., & Ferreira, F. (2017). Allergens of Blomia tropicalis: An Overview of Recombinant Molecules. International Archives of Allergy and Immunology, 172(4), 203-214. https://doi.org/10.1159/000464325