Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases

Alaa Alhayek; Ahmed S Abdelsamie; Esther Schönauer; Virgyl Camberlein; Evelyn Hutterer; Gernot Posselt; Jamil Serwanja; Constantin Blöchl; Christian G Huber; Jörg Haupenthal; Hans Brandstetter; Silja Wessler; Anna K H Hirsch

doi:10.1021/acs.jmedchem.2c00785

Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases

Alaa Alhayek, Ahmed S Abdelsamie, Esther Schönauer, Virgyl Camberlein, Evelyn Hutterer, Gernot Posselt, Jamil Serwanja, Constantin Blöchl, Christian G Huber, Jörg Haupenthal, Hans Brandstetter, Silja Wessler, Anna K H Hirsch

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	12933-12955
Number of pages	23
Journal	Journal of Medicinal Chemistry
Volume	65
Issue number	19
Early online date	26 Sept 2022
DOIs	https://doi.org/10.1021/acs.jmedchem.2c00785
Publication status	Published - 2022

Bibliographical note

Publisher Copyright:
© 2022 American Chemical Society.

Keywords

inhibitors
Pseudomonas aeruginosa elastase (LasB)
Collagenase ColH
Clostridium histolyticum
Collagenases/metabolism
Diphosphonates
Matrix Metalloproteinase Inhibitors
Microbial Collagenase

Fields of Science and Technology Classification 2012

104 Chemistry
106 Biology

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10.1021/acs.jmedchem.2c00785

Cite this

Alhayek, A., Abdelsamie, A. S., Schönauer, E., Camberlein, V., Hutterer, E., Posselt, G., Serwanja, J., Blöchl, C., Huber, C. G., Haupenthal, J., Brandstetter, H., Wessler, S., & Hirsch, A. K. H. (2022). Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases. Journal of Medicinal Chemistry, 65(19), 12933-12955. https://doi.org/10.1021/acs.jmedchem.2c00785

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title = "Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases",

keywords = "inhibitors, Pseudomonas aeruginosa elastase (LasB), Collagenase ColH, Clostridium histolyticum, Collagenases/metabolism, Diphosphonates, Matrix Metalloproteinase Inhibitors, Microbial Collagenase",

author = "Alaa Alhayek and Abdelsamie, {Ahmed S} and Esther Sch{\"o}nauer and Virgyl Camberlein and Evelyn Hutterer and Gernot Posselt and Jamil Serwanja and Constantin Bl{\"o}chl and Huber, {Christian G} and J{\"o}rg Haupenthal and Hans Brandstetter and Silja Wessler and Hirsch, {Anna K H}",

note = "Publisher Copyright: {\textcopyright} 2022 American Chemical Society.",

year = "2022",

doi = "10.1021/acs.jmedchem.2c00785",

language = "English",

volume = "65",

pages = "12933--12955",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

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Alhayek, A, Abdelsamie, AS, Schönauer, E, Camberlein, V, Hutterer, E, Posselt, G, Serwanja, J, Blöchl, C, Huber, CG, Haupenthal, J, Brandstetter, H, Wessler, S & Hirsch, AKH 2022, 'Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases', Journal of Medicinal Chemistry, vol. 65, no. 19, pp. 12933-12955. https://doi.org/10.1021/acs.jmedchem.2c00785

TY - JOUR

T1 - Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases

AU - Alhayek, Alaa

AU - Abdelsamie, Ahmed S

AU - Schönauer, Esther

AU - Camberlein, Virgyl

AU - Hutterer, Evelyn

AU - Posselt, Gernot

AU - Serwanja, Jamil

AU - Blöchl, Constantin

AU - Huber, Christian G

AU - Haupenthal, Jörg

AU - Brandstetter, Hans

AU - Wessler, Silja

AU - Hirsch, Anna K H

PY - 2022

Y1 - 2022

KW - inhibitors

KW - Pseudomonas aeruginosa elastase (LasB)

KW - Collagenase ColH

KW - Clostridium histolyticum

KW - Collagenases/metabolism

KW - Diphosphonates

KW - Matrix Metalloproteinase Inhibitors

KW - Microbial Collagenase

UR - http://www.scopus.com/inward/record.url?scp=85139238231&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/bb6e21c5-4ab0-35ba-9d84-c6d040916ebb/

U2 - 10.1021/acs.jmedchem.2c00785

DO - 10.1021/acs.jmedchem.2c00785

M3 - Article

C2 - 36154055

SN - 0022-2623

VL - 65

SP - 12933

EP - 12955

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 19

ER -

Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases

Bibliographical note

Keywords

Fields of Science and Technology Classification 2012

Access to Document

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Cite this