Gender differentiates effects of acoustic stimulation in patients with tinnitus

Marta Partyka*, Patrick Neff, Timothée Bacri, Jakob Michels, Nathan Weisz, Winfried Schlee

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding/Legal commentaryChapter in BookResearchpeer-review


Gender constitutes a major factor to consider when tailoring subtype-based therapies for tinnitus. Previous reports showed important differences between men and women concerning basic perceptual tinnitus characteristics (i.e., laterality, frequency, tinnitus loudness) as well as psychological reactions linked to this condition. Therapeutic approaches based on acoustic stimulation involve processes beyond a pure masking effect and consist of sound presentation temporarily altering or alleviating tinnitus perception via residual and/or lateral inhibition mechanisms. Presented stimuli may include pure tones, noise, and music adjusted to or modulated to filter out tinnitus pitch and therefore trigger reparative functional and structural changes in the auditory system. Furthermore, recent findings suggest that in tonal tinnitus, the presentation of pitch-adjusted sounds which were altered by a 10 Hz modulation of amplitude was more efficient than unmodulated stimulation.

In this paper, we investigate sex differences in the outcome of different variants of acoustic stimulation, looking for factors revealing predictive value in the efficiency of tinnitus relief.
Original languageEnglish
Title of host publicationProgress in Brain Research
Subtitle of host publicationTinnitus - An Interdisciplinary Approach Towards Individualized Treatment: Results from the European Graduate School for Interdisciplinary Tinnitus Research
EditorsBerthold Langguth, Tobias Kleinjung, Dirk De Ridder, Winfried Schlee, Sven Vanneste
Place of PublicationAmsterdam
Number of pages33
ISBN (Print)978-0-12-822377-2
Publication statusPublished - 20 May 2021

Publication series

NameProgress in Brain Research
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855

Bibliographical note

Publisher Copyright:
© 2021 Elsevier B.V.

Copyright 2021 Elsevier B.V., All rights reserved.

Fields of Science and Technology Classification 2012

  • 301 Medical-Theoretical Sciences, Pharmacy
  • 501 Psychology


  • Gender
  • Sex differences
  • Tinnitus
  • Tinnitus treatment
  • Auditory
  • Acoustic stimulation
  • Sound therapy
  • Notched music
  • Amplitude modulation
  • Alpha

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