In silico Design of Phl p 6 Variants With Altered Fold-Stability Significantly Impacts Antigen Processing, Immunogenicity and Immune Polarization

Petra Winter, Stefan Stubenvoll, Sandra Scheiblhofer, Isabella A. Joubert, Lisa Strasser, Carolin Briganser, Wai Tuck Soh, Florian Hofer, Anna Sophia Kamenik, Valentin Dietrich, Sara Michelini, Josef Laimer, Peter Lackner, Jutta Horejs-Hoeck, Martin Tollinger, Klaus R. Liedl, Johann Brandstetter, Christian G. Huber, Richard Weiss

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article number1824
JournalFrontiers in Immunology
Publication statusPublished - 18 Aug 2020

Bibliographical note

Copyright © 2020 Winter, Stubenvoll, Scheiblhofer, Joubert, Strasser, Briganser, Soh, Hofer, Kamenik, Dietrich, Michelini, Laimer, Lackner, Horejs-Hoeck, Tollinger, Liedl, Brandstetter, Huber and Weiss.


  • antigen processing and presentation
  • endolysosomal degradation
  • immune polarization
  • in silico mutagenesis
  • in silico mutant screening
  • protein stabilization
  • structural stability

Fields of Science and Technology Classification 2012

  • 106 Biology

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