Knockdown of Endogenous Nucb2/Nesfatin-1 in the PVN Leads to Obese-Like Phenotype and Abolishes the Metformin- and Stress-Induced Thermogenic Response in Rats

Daniel Stephan; Natalie Taege; Riccardo Dore; Julica Folberth; Olaf Jöhren; Markus Schwaninger; Hendrik Lehnert; Carla Schulz

doi:10.1055/a-1926-7280

Knockdown of Endogenous Nucb2/Nesfatin-1 in the PVN Leads to Obese-Like Phenotype and Abolishes the Metformin- and Stress-Induced Thermogenic Response in Rats

Daniel Stephan, Natalie Taege, Riccardo Dore, Julica Folberth, Olaf Jöhren, Markus Schwaninger, Hendrik Lehnert, Carla Schulz

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Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	768-779
Number of pages	12
Journal	Hormone and Metabolic Research
Volume	54
Issue number	11
Early online date	4 Oct 2022
DOIs	https://doi.org/10.1055/a-1926-7280
Publication status	Published - Nov 2022

Bibliographical note

Publisher Copyright:
© 2022 Georg Thieme Verlag. All rights reserved.

Keywords

Animals
Calcium-Binding Proteins/genetics
DNA-Binding Proteins/genetics
Gene Knockdown Techniques
Male
Metformin/pharmacology
Nerve Tissue Proteins/genetics
Nucleobindins/genetics
Obesity/etiology
Paraventricular Hypothalamic Nucleus
Phenotype
Rats
Rats, Wistar
Thermogenesis/genetics
NTS
metabolic syndrome
brown adipose tissue
diabetes
energy homeostasis
hypothalamus
obesity
oral antidiabetic drugs; OAD

Fields of Science and Technology Classification 2012

302 Clinical Medicine

Access to Document

10.1055/a-1926-7280

Cite this

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title = "Knockdown of Endogenous Nucb2/Nesfatin-1 in the PVN Leads to Obese-Like Phenotype and Abolishes the Metformin- and Stress-Induced Thermogenic Response in Rats",

keywords = "Animals, Calcium-Binding Proteins/genetics, DNA-Binding Proteins/genetics, Gene Knockdown Techniques, Male, Metformin/pharmacology, Nerve Tissue Proteins/genetics, Nucleobindins/genetics, Obesity/etiology, Paraventricular Hypothalamic Nucleus, Phenotype, Rats, Rats, Wistar, Thermogenesis/genetics, NTS, metabolic syndrome, brown adipose tissue, diabetes, energy homeostasis, hypothalamus, obesity, oral antidiabetic drugs; OAD",

author = "Daniel Stephan and Natalie Taege and Riccardo Dore and Julica Folberth and Olaf J{\"o}hren and Markus Schwaninger and Hendrik Lehnert and Carla Schulz",

year = "2022",

month = nov,

doi = "10.1055/a-1926-7280",

language = "English",

volume = "54",

pages = "768--779",

journal = "Hormone and Metabolic Research",

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TY - JOUR

T1 - Knockdown of Endogenous Nucb2/Nesfatin-1 in the PVN Leads to Obese-Like Phenotype and Abolishes the Metformin- and Stress-Induced Thermogenic Response in Rats

AU - Stephan, Daniel

AU - Taege, Natalie

AU - Dore, Riccardo

AU - Folberth, Julica

AU - Jöhren, Olaf

AU - Schwaninger, Markus

AU - Lehnert, Hendrik

AU - Schulz, Carla

PY - 2022/11

Y1 - 2022/11

KW - Animals

KW - Calcium-Binding Proteins/genetics

KW - DNA-Binding Proteins/genetics

KW - Gene Knockdown Techniques

KW - Male

KW - Metformin/pharmacology

KW - Nerve Tissue Proteins/genetics

KW - Nucleobindins/genetics

KW - Obesity/etiology

KW - Paraventricular Hypothalamic Nucleus

KW - Phenotype

KW - Rats

KW - Rats, Wistar

KW - Thermogenesis/genetics

KW - NTS

KW - metabolic syndrome

KW - brown adipose tissue

KW - diabetes

KW - energy homeostasis

KW - hypothalamus

KW - obesity

KW - oral antidiabetic drugs; OAD

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UR - http://www.scopus.com/inward/record.url?scp=85141891564&partnerID=8YFLogxK

U2 - 10.1055/a-1926-7280

DO - 10.1055/a-1926-7280

M3 - Article

C2 - 36195118

SN - 0018-5043

VL - 54

SP - 768

EP - 779

JO - Hormone and Metabolic Research

JF - Hormone and Metabolic Research

IS - 11

ER -

Knockdown of Endogenous Nucb2/Nesfatin-1 in the PVN Leads to Obese-Like Phenotype and Abolishes the Metformin- and Stress-Induced Thermogenic Response in Rats

Bibliographical note

Keywords

Fields of Science and Technology Classification 2012

Access to Document

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Cite this