MAESTROweb: a web server for structure based protein stability prediction: a web server for structure-based protein stability prediction

Josef Laimer, Julia Hiebl-Flach, Daniel Lengauer, Peter Lackner

Research output: Contribution to journalArticle

Abstract

UNLABELLED: The prediction of change in stability upon point mutations in proteins has many applications in protein analysis and engineering. We recently adjoined a new structure-based method called MAESTRO, which is distributed as command line program. We now provide access to the most important features of MAESTRO by an easy to use web service. MAESTROweb allows the prediction of change in stability for user-defined mutations, provides a scan functionality for the most (de)stabilizing n-point mutations for a maximum of n = 5, creates mutation sensitivity profiles and evaluates potential disulfide bonds. MAESTROweb operates on monomers, multimers and biological assemblies as defined by PDB.

AVAILABILITY AND IMPLEMENTATION: MAESTROweb is freely available for non-commercial use at https://biwww.che.sbg.ac.at/maestro/web

CONTACT: peter.lackner@sbg.ac.at.

Translated title of the contributionMAESTROweb: a web server for structure based protein stability prediction
Original languageEnglish
Pages (from-to)1414-6
Number of pages3
JournalBioinformatics
Volume32
Issue number9
DOIs
Publication statusPublished - 1 May 2016

Bibliographical note

© The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Fields of Science and Technology Classification 2012

  • 106 Biology
  • 102 Computer Sciences

Keywords

  • Computers
  • Protein Stability
  • Proteins/chemistry
  • Software
  • Web Browser

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