Mechanisms and clinical relevance of the bidirectional relationship of viral infections with metabolic diseases

Nikolaos Perakakis; Hani Harb; Benjamin G Hale; Zsuzsanna Varga; Charlotte Steenblock; Waldemar Kanczkowski; Vasileia Ismini Alexaki; Barbara Ludwig; Peter Mirtschink; Michele Solimena; Nicole Toepfner; Sebastian Zeissig; Manuel Gado; Irene Alma Abela; Felix Beuschlein; Giatgen A Spinas; Claudia Cavelti-Weder; Philipp A Gerber; Michael Huber; Alexandra Trkola; Milo A Puhan; Wendy Wei-Lynn Wong; Andreas Linkermann; Viswanathan Mohan; Hendrik Lehnert; Peter Nawroth; Triantafyllos Chavakis; Geltrude Mingrone; Christian Wolfrum; Annelies S Zinkernagel; Stefan R Bornstein

doi:10.1016/S2213-8587(23)00154-7

Mechanisms and clinical relevance of the bidirectional relationship of viral infections with metabolic diseases

Nikolaos Perakakis, Hani Harb, Benjamin G Hale, Zsuzsanna Varga, Charlotte Steenblock, Waldemar Kanczkowski, Vasileia Ismini Alexaki, Barbara Ludwig, Peter Mirtschink, Michele Solimena, Nicole Toepfner, Sebastian Zeissig, Manuel Gado, Irene Alma Abela, Felix Beuschlein, Giatgen A Spinas, Claudia Cavelti-Weder, Philipp A Gerber, Michael Huber, Alexandra TrkolaMilo A Puhan, Wendy Wei-Lynn Wong, Andreas Linkermann, Viswanathan Mohan, Hendrik Lehnert, Peter Nawroth, Triantafyllos Chavakis, Geltrude Mingrone, Christian Wolfrum, Annelies S Zinkernagel, Stefan R Bornstein

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Abstract

Viruses have been present during all evolutionary steps on earth and have had a major effect on human history. Viral infections are still among the leading causes of death. Another public health concern is the increase of non-communicable metabolic diseases in the last four decades. In this Review, we revisit the scientific evidence supporting the presence of a strong bidirectional feedback loop between several viral infections and metabolic diseases. We discuss how viruses might lead to the development or progression of metabolic diseases and conversely, how metabolic diseases might increase the severity of a viral infection. Furthermore, we discuss the clinical relevance of the current evidence on the relationship between viral infections and metabolic disease and the present and future challenges that should be addressed by the scientific community and health authorities.

Original language	English
Pages (from-to)	675-693
Number of pages	19
Journal	The Lancet Diabetes and Endocrinology
Volume	11
Issue number	9
Early online date	28 Jul 2023
DOIs	https://doi.org/10.1016/S2213-8587(23)00154-7
Publication status	Published - Sept 2023

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Ltd

Fields of Science and Technology Classification 2012

302 Clinical Medicine

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10.1016/S2213-8587(23)00154-7

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Perakakis, N., Harb, H., Hale, B. G., Varga, Z., Steenblock, C., Kanczkowski, W., Alexaki, V. I., Ludwig, B., Mirtschink, P., Solimena, M., Toepfner, N., Zeissig, S., Gado, M., Abela, I. A., Beuschlein, F., Spinas, G. A., Cavelti-Weder, C., Gerber, P. A., Huber, M., ... Bornstein, S. R. (2023). Mechanisms and clinical relevance of the bidirectional relationship of viral infections with metabolic diseases. The Lancet Diabetes and Endocrinology, 11(9), 675-693. https://doi.org/10.1016/S2213-8587(23)00154-7

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abstract = "Viruses have been present during all evolutionary steps on earth and have had a major effect on human history. Viral infections are still among the leading causes of death. Another public health concern is the increase of non-communicable metabolic diseases in the last four decades. In this Review, we revisit the scientific evidence supporting the presence of a strong bidirectional feedback loop between several viral infections and metabolic diseases. We discuss how viruses might lead to the development or progression of metabolic diseases and conversely, how metabolic diseases might increase the severity of a viral infection. Furthermore, we discuss the clinical relevance of the current evidence on the relationship between viral infections and metabolic disease and the present and future challenges that should be addressed by the scientific community and health authorities.",

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month = sep,

doi = "10.1016/S2213-8587(23)00154-7",

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Perakakis, N, Harb, H, Hale, BG, Varga, Z, Steenblock, C, Kanczkowski, W, Alexaki, VI, Ludwig, B, Mirtschink, P, Solimena, M, Toepfner, N, Zeissig, S, Gado, M, Abela, IA, Beuschlein, F, Spinas, GA, Cavelti-Weder, C, Gerber, PA, Huber, M, Trkola, A, Puhan, MA, Wong, WW-L, Linkermann, A, Mohan, V, Lehnert, H, Nawroth, P, Chavakis, T, Mingrone, G, Wolfrum, C, Zinkernagel, AS & Bornstein, SR 2023, 'Mechanisms and clinical relevance of the bidirectional relationship of viral infections with metabolic diseases', The Lancet Diabetes and Endocrinology, vol. 11, no. 9, pp. 675-693. https://doi.org/10.1016/S2213-8587(23)00154-7

TY - JOUR

T1 - Mechanisms and clinical relevance of the bidirectional relationship of viral infections with metabolic diseases

AU - Perakakis, Nikolaos

AU - Harb, Hani

AU - Hale, Benjamin G

AU - Varga, Zsuzsanna

AU - Steenblock, Charlotte

AU - Kanczkowski, Waldemar

AU - Alexaki, Vasileia Ismini

AU - Ludwig, Barbara

AU - Mirtschink, Peter

AU - Solimena, Michele

AU - Toepfner, Nicole

AU - Zeissig, Sebastian

AU - Gado, Manuel

AU - Abela, Irene Alma

AU - Beuschlein, Felix

AU - Spinas, Giatgen A

AU - Cavelti-Weder, Claudia

AU - Gerber, Philipp A

AU - Huber, Michael

AU - Trkola, Alexandra

AU - Puhan, Milo A

AU - Wong, Wendy Wei-Lynn

AU - Linkermann, Andreas

AU - Mohan, Viswanathan

AU - Lehnert, Hendrik

AU - Nawroth, Peter

AU - Chavakis, Triantafyllos

AU - Mingrone, Geltrude

AU - Wolfrum, Christian

AU - Zinkernagel, Annelies S

AU - Bornstein, Stefan R

PY - 2023/9

Y1 - 2023/9

N2 - Viruses have been present during all evolutionary steps on earth and have had a major effect on human history. Viral infections are still among the leading causes of death. Another public health concern is the increase of non-communicable metabolic diseases in the last four decades. In this Review, we revisit the scientific evidence supporting the presence of a strong bidirectional feedback loop between several viral infections and metabolic diseases. We discuss how viruses might lead to the development or progression of metabolic diseases and conversely, how metabolic diseases might increase the severity of a viral infection. Furthermore, we discuss the clinical relevance of the current evidence on the relationship between viral infections and metabolic disease and the present and future challenges that should be addressed by the scientific community and health authorities.

AB - Viruses have been present during all evolutionary steps on earth and have had a major effect on human history. Viral infections are still among the leading causes of death. Another public health concern is the increase of non-communicable metabolic diseases in the last four decades. In this Review, we revisit the scientific evidence supporting the presence of a strong bidirectional feedback loop between several viral infections and metabolic diseases. We discuss how viruses might lead to the development or progression of metabolic diseases and conversely, how metabolic diseases might increase the severity of a viral infection. Furthermore, we discuss the clinical relevance of the current evidence on the relationship between viral infections and metabolic disease and the present and future challenges that should be addressed by the scientific community and health authorities.

UR - https://www.thelancet.com/journals/landia/article/PIIS2213-8587(23)00154-7/fulltext

UR - http://www.scopus.com/inward/record.url?scp=85168735022&partnerID=8YFLogxK

U2 - 10.1016/S2213-8587(23)00154-7

DO - 10.1016/S2213-8587(23)00154-7

M3 - Review article

C2 - 37524103

SN - 2213-8587

VL - 11

SP - 675

EP - 693

JO - The Lancet Diabetes and Endocrinology

JF - The Lancet Diabetes and Endocrinology

IS - 9

ER -

Mechanisms and clinical relevance of the bidirectional relationship of viral infections with metabolic diseases

Abstract

Bibliographical note

Fields of Science and Technology Classification 2012

Access to Document

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