TY - JOUR
T1 - Reduced intrinsic neural timescales in schizophrenia along posterior parietal and occipital areas
AU - Uscătescu, Lavinia Carmen
AU - Said-Yürekli, Sarah
AU - Kronbichler, Lisa
AU - Stelzig-Schöler, Renate
AU - Pearce, Brandy-Gale
AU - Reich, Luise Antonia
AU - Weber, Stefanie
AU - Aichhorn, Wolfgang
AU - Kronbichler, Martin
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/11/22
Y1 - 2021/11/22
N2 - We computed intrinsic neural timescales (INT) based on resting-state functional magnetic resonance imaging (rsfMRI) data of healthy controls (HC) and patients with schizophrenia spectrum disorder (SZ) from three independently collected samples. Five clusters showed decreased INT in SZ compared to HC in all three samples: right occipital fusiform gyrus (rOFG), left superior occipital gyrus (lSOG), right superior occipital gyrus (rSOG), left lateral occipital cortex (lLOC) and right postcentral gyrus (rPG). In other words, it appears that sensory information in visual and posterior parietal areas is stored for reduced lengths of time in SZ compared to HC. Finally, we found that symptom severity appears to modulate INT of these areas in SZ.
AB - We computed intrinsic neural timescales (INT) based on resting-state functional magnetic resonance imaging (rsfMRI) data of healthy controls (HC) and patients with schizophrenia spectrum disorder (SZ) from three independently collected samples. Five clusters showed decreased INT in SZ compared to HC in all three samples: right occipital fusiform gyrus (rOFG), left superior occipital gyrus (lSOG), right superior occipital gyrus (rSOG), left lateral occipital cortex (lLOC) and right postcentral gyrus (rPG). In other words, it appears that sensory information in visual and posterior parietal areas is stored for reduced lengths of time in SZ compared to HC. Finally, we found that symptom severity appears to modulate INT of these areas in SZ.
KW - Biomarkers
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=85119658438&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/34811376/
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608811/
UR - https://europepmc.org/article/MED/34811376
UR - https://www.mendeley.com/catalogue/cac4b90c-08a7-36ff-8e89-743641b8429b/
U2 - 10.1038/s41537-021-00184-x
DO - 10.1038/s41537-021-00184-x
M3 - Article
C2 - 34811376
SN - 2334-265X
VL - 7
JO - npj Schizophrenia
JF - npj Schizophrenia
M1 - 55
ER -