Structure-Based Characterization of Multiprotein Complexes

Markus Wiederstein, Markus Gruber, Karl Frank, Francisco Melo, Manfred J Sippl

    Research output: Contribution to journalArticle

    Abstract

    Multiprotein complexes govern virtually all cellular processes. Their 3D structures provide important clues to their biological roles, especially through structural correlations among protein molecules and complexes. The detection of such correlations generally requires comprehensive searches in databases of known protein structures by means of appropriate structure-matching techniques. Here, we present a high-speed structure search engine capable of instantly matching large protein oligomers against the complete and up-to-date database of biologically functional assemblies of protein molecules. We use this tool to reveal unseen structural correlations on the level of protein quaternary structure and demonstrate its general usefulness for efficiently exploring complex structural relationships among known protein assemblies.

    Translated title of the contributionStructure-Based Characterization of Multiprotein Complexes
    Original languageEnglish
    Pages (from-to)1063-1070
    Number of pages8
    JournalStructure
    Volume22
    Issue number7
    DOIs
    Publication statusPublished - 8 Jul 2014

    Bibliographical note

    Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

    Fields of Science and Technology Classification 2012

    • 102 Computer Sciences
    • 106 Biology

    Keywords

    • Algorithms
    • Computational Biology/methods
    • Databases, Protein
    • Information Storage and Retrieval/methods
    • Internet
    • Models, Molecular
    • Multiprotein Complexes/chemistry
    • Protein Conformation
    • Protein Structure, Quaternary
    • Reproducibility of Results

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