The Temporal Dynamics of Aperiodic Neural Activity Track Changes in Sleep Architecture

Mohamed Ameen*, Joshua Jacobs, Manuel Schabus, Kerstin Hödlmoser, Thomas Donoghue

*Corresponding author for this work

Research output: Working paper/PreprintPreprint

Abstract

The aperiodic (1/f-like) component of electrophysiological data - whereby power systematically decreases with increasing frequency, as quantified by the aperiodic exponent - has been shown to differentiate sleep stages. Earlier work, however, has typically focused on measuring the aperiodic exponent across a narrow frequency range. In this work, we sought to further investigate aperiodic activity during sleep by extending these analyses across broader frequency ranges and considering alternate model definitions. This included measuring ‘knees’ in the aperiodic component, which reflect bends in the power spectrum, indicating a change in the exponent. We also sought to evaluate the temporal dynamics of aperiodic activity during sleep. To do so, we analyzed data from two sources: intracranial EEG (iEEG) from 106 epilepsy patients and high-density EEG from 17 healthy individuals, and measured aperiodic activity, explicitly comparing different frequency ranges and model forms. In doing so, we find that fitting broadband aperiodic models and incorporating a ‘knee’ feature effectively captures sleep-stage-dependent differences in aperiodic activity as well as temporal dynamics that relate to sleep stage transitions and responses to external stimuli. In particular, the knee parameter shows stage-specific variation, suggesting an interpretation of varying timescales across sleep stages. These results demonstrate that examining broader frequency ranges with the more complex aperiodic models reveals novel insights and interpretations for understanding aperiodic neural activity during sleep.
Original languageEnglish
PublisherbioRxiv
Number of pages51
DOIs
Publication statusPublished - 26 Jan 2024

Keywords

  • sleep
  • aperiodic activity
  • spectral exponent
  • 1/f
  • knee frequency
  • iEEG
  • EEG

Fields of Science and Technology Classification 2012

  • 501 Psychology

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